ChEMBL ligand: CHEMBL359482
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] There should be some charts here, you may need to enable JavaScript!
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of Gsk3beta	B	7.66	pKi	22	nM	Ki	J Med Chem (2009) 52: 2629-2651 [PMID:19320489]
ChEMBL	Inhibition of GSK3-beta	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3586-3592 [PMID:19447622]
GtoPdb	-	-	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3586-92 [PMID:19447622]
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
ChEMBL	Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay	B	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4108-4114 [PMID:21632247]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL	Inhibition of aurora A kinase	B	7.24	pKi	58	nM	Ki	J Med Chem (2009) 52: 2629-2651 [PMID:19320489]
ChEMBL	Inhibition of Aurora-A by coupled assay	B	7.24	pKi	58	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3586-3592 [PMID:19447622]
GtoPdb	-	-	7.24	pKi	58	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3586-92 [PMID:19447622]
ChEMBL	Inhibition of Aurora A (unknown origin) using FAM-labelled peptide as substrate pretreated for 10 mins followed by substrate addition and measured after 60 mins by fluorescence assay	B	7.55	pIC50	28	nM	IC50	Eur J Med Chem (2018) 157: 1361-1375 [PMID:30196060]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
GtoPdb	-	-	7.09	pKi	81	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3586-92 [PMID:19447622]
ChEMBL	Inhibition of Src	B	7.09	pKi	81	nM	Ki	J Med Chem (2009) 52: 2629-2651 [PMID:19320489]
ChEMBL	Inhibition of Src	B	7.09	pKi	81	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3586-3592 [PMID:19447622]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]