GSK-3 inhibitor X [Ligand Id: 5975] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL430226 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aryl hydrocarbon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3201] [GtoPdb: 2951] [UniProtKB: P35869] | ||||||||
| ChEMBL | Agonist activity at human aryl hydrocarbon receptor | F | 6.8 | pEC50 | 160 | nM | EC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
| ChEMBL | Inhibitory activity against cyclin dependent kinase 1-cyclinB from starfish (Marthasterias glacialis) oocytes | B | 4.2 | pIC50 | 63000 | nM | IC50 | J Med Chem (2004) 47: 935-946 [PMID:14761195] |
| ChEMBL | Inhibition of CDK1/cyclinB | B | 4.2 | pIC50 | 63000 | nM | IC50 | Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
| ChEMBL | Inhibitory activity against Cyclin-dependent kinase 5-p35nck5a | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Med Chem (2004) 47: 935-946 [PMID:14761195] |
| glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029] | ||||||||
| GtoPdb | Measured using GSK3 as a complex of α and β isozymes, isolated from pig brain | - | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2004) 47: 935-46 [PMID:14761195] |
| glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030] | ||||||||
| GtoPdb | Measured using GSK3 as a complex of α and β isozymes, isolated from pig brain | - | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2004) 47: 935-46 [PMID:14761195] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
