GSK-3 inhibitor IX [Ligand Id: 5974] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2178734 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| GtoPdb | CDK1/cyclin B complex | - | 6.49 | pIC50 | 320 | nM | IC50 |
J Med Chem (2004) 47: 935-46 [PMID:14761195]; Chem Biol (2003) 10: 1255-66 [PMID:14700633] |
| cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
| GtoPdb | CDK5/p25 complex | - | 7.08 | pIC50 | 83 | nM | IC50 |
J Med Chem (2004) 47: 935-46 [PMID:14761195]; Chem Biol (2003) 10: 1255-66 [PMID:14700633] |
| glycogen synthase kinase 3 alpha in Pig [GtoPdb: 2029] | ||||||||
| GtoPdb | GSK3α/β complex from pig brain | - | 8.3 | pIC50 | 5 | nM | IC50 |
J Med Chem (2004) 47: 935-46 [PMID:14761195]; Chem Biol (2003) 10: 1255-66 [PMID:14700633] |
| glycogen synthase kinase 3 beta in Pig [GtoPdb: 2030] | ||||||||
| GtoPdb | GSK3α/β complex from pig brain | - | 8.3 | pIC50 | 5 | nM | IC50 |
J Med Chem (2004) 47: 935-46 [PMID:14761195]; Chem Biol (2003) 10: 1255-66 [PMID:14700633] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
