Gö 6976 [Ligand Id: 5973] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL302449 (Go-6976)
  • cAMP-dependent protein kinase alpha-catalytic subunit in Bovine [ChEMBL: CHEMBL2654] [UniProtKB: P00517]
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  • cGMP-dependent protein kinase 1 alpha in Bovine [ChEMBL: CHEMBL3183] [UniProtKB: P00516]
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  • Myosin light chain kinase, smooth muscle in Chicken [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
  • myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
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  • sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6]
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
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  • protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • protein kinase C gamma/Protein kinase C gamma in Human [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
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  • protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
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  • polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
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  • BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Mouse [ChEMBL: CHEMBL3343] [GtoPdb: 1940] [UniProtKB: P16277]
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  • fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cAMP-dependent protein kinase alpha-catalytic subunit in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2654] [UniProtKB: P00517]
ChEMBL In vitro for inhibitory activity against cAMP-dependent protein kinase from bovine heart (A-kinase) B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. Lett. (1993) 3: 1959-1964
cGMP-dependent protein kinase 1 alpha in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3183] [UniProtKB: P00516]
ChEMBL In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase) B 5.21 pIC50 6200 nM IC50 Bioorg. Med. Chem. Lett. (1993) 3: 1959-1964
ChEMBL Tested for inhibition of cGMP-dependent protein kinase from bovine lung B 5.21 pIC50 6200 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 55-60
Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
ChEMBL In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase) B 5.24 pIC50 5800 nM IC50 Bioorg. Med. Chem. Lett. (1993) 3: 1959-1964
myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
ChEMBL Tested for inhibition of Myosin light chain kinase from chicken gizzard B 5.24 pIC50 5800 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 55-60
sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6]
ChEMBL Inhibition of human recombinant SIRT2 B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2006) 49: 7307-7316 [PMID:17149860]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Inhibition of PKCalpha by TR-FRET assay B 8.43 pIC50 3.7 nM IC50 J. Med. Chem. (2010) 53: 5400-5421 [PMID:20684591]
ChEMBL Inhibition of PKCalpha B 8.64 pIC50 2.3 nM IC50 J. Biol. Chem. (2007) 282: 15208-15216 [PMID:17395590]
GtoPdb - - 8.64 pIC50 2.3 nM IC50 J Biol Chem (1993) 268: 9194-7 [PMID:8486620]
ChEMBL Inhibition of PKCalpha B 8.7 pIC50 2 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL Inhibition of PKCbeta1 B 8.21 pIC50 6.2 nM IC50 J. Biol. Chem. (2007) 282: 15208-15216 [PMID:17395590]
ChEMBL Inhibition of PKCbeta B 8.7 pIC50 2 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL Inhibition of PKCdelta by TR-FRET assay B 6.35 pIC50 446 nM IC50 J. Med. Chem. (2010) 53: 5400-5421 [PMID:20684591]
protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
ChEMBL Inhibition of PKCgamma B 8.7 pIC50 2 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-20528 [PMID:18077363]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
ChEMBL Inhibition of PKD1 assessed as HDAC5 neuclear export B 7.21 pIC50 62 nM IC50 J. Med. Chem. (2010) 53: 5400-5421 [PMID:20684591]
ChEMBL Inhibition of PKD1 by TR-FRET assay B 7.57 pIC50 27 nM IC50 J. Med. Chem. (2010) 53: 5400-5421 [PMID:20684591]
GtoPdb - - 7.7 pIC50 20 nM IC50 FEBS Lett (1996) 392: 77-80 [PMID:8772178]
polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
ChEMBL Inhibition of human PLK4 B 8.47 pKi 3.4 nM Ki J. Med. Chem. (2013) 56: 6069-6087 [PMID:23829549]
BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3343] [GtoPdb: 1940] [UniProtKB: P16277]
ChEMBL Tested for inhibition of general tyrosine-specific protein kinase activity from murine B cell lysate B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 55-60
fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888]
GtoPdb Inhibitory activity against recombinant FLT3 in an in vitro kinase assay. - 9.15 pIC50 0.7 nM IC50 Biochem Pharmacol (2014) 90: 16-24 [PMID:24735609]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]