alsterpaullone 2-cyanoethyl [Ligand Id: 5926] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL260138 (2-Cyanoethyl Alsterpaullone)
  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
Created with Highcharts 10.3.3ValuesChart context menuGlycogen synthase kinase-3 betapKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
Created with Highcharts 10.3.3ValuesChart context menuPlatelet-derived growth factor receptor betapKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase SRCpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
Created with Highcharts 10.3.3ValuesChart context menuVascular endothelial growth factor receptor 2pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
Created with Highcharts 10.3.3ValuesChart context menuVascular endothelial growth factor receptor 3pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
Created with Highcharts 10.3.3ValuesChart context menucyclin dependent kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human024681012Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of GSK3-beta B 7 pIC50 100 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Inhibition of GSK3-beta B 9.1 pIC50 0.8 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb - - 9.1 pIC50 0.8 nM IC50 Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL Inhibition of PDGFRbeta B 6.5 pIC50 316.23 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Inhibition of Src B 6.5 pIC50 316.23 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Inhibition of VEGFR2 B 6 pIC50 1000 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
ChEMBL Inhibition of VEGFR3 B 6 pIC50 1000 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb CDK1 in association with cyclin B - 9.64 pIC50 0.23 nM IC50 Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]