aloisine [Ligand Id: 5923] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL306498 (Aloisine)
Created with Highcharts 10.3.3ValuesChart context menuCyclin-dependent kinase 1/cyclin BpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCyclin-dependent kinase 2/cyclin E1pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078]
Created with Highcharts 10.3.3ValuesChart context menuCyclin-dependent kinase 5/CDK5 activator 1pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
Created with Highcharts 10.3.3ValuesChart context menuGlycogen synthase kinase-3 betapKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
Created with Highcharts 10.3.3ValuesChart context menuProtein tyrosine kinase 2 betapKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase ZAP-70pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7]
ChEMBL Inhibitory activity against cyclin-dependent kinase 1-cyclin B in starfish B 6.15 pIC50 700 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941]
GtoPdb Measuring inhibition of CDK2 in association with cyclin E - 9.28 pKi 0.53 nM Ki J Med Chem (2012) 55: 1926-39 [PMID:22289061]
ChEMBL Inhibition of human recombinant CDK2/CycE using HHASPRK as substrate by ESI-MS analysis B 9.28 pKi 0.52 nM Ki J Med Chem (2012) 55: 1926-1939 [PMID:22289061]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078]
ChEMBL Inhibitory activity against recombinant mammalian cyclin-dependent kinase 5 (p35 NCK5a) expressed in Escherichia coli B 5.82 pIC50 1500 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of glycogen synthase kinase-3 beta, purified from porcine brain or expressed in and purified from insect Sf9 cells B 6.04 pIC50 920 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
GtoPdb - - 6.03 pKi 933 nM Ki J Med Chem (2012) 55: 1926-39 [PMID:22289061]
ChEMBL Inhibition of human recombinant PYK2 by ESI-MS analysis B 6.03 pKi 933.25 nM Ki J Med Chem (2012) 55: 1926-1939 [PMID:22289061]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL Inhibition of human recombinant ZAP70 using EEEEYEEEE as substrate by ESI-MS analysis B 5.58 pKi 2630.27 nM Ki J Med Chem (2012) 55: 1926-1939 [PMID:22289061]
GtoPdb - - 5.58 pKi 2630 nM Ki J Med Chem (2012) 55: 1926-39 [PMID:22289061]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]