aloisine [Ligand Id: 5923] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL306498 (Aloisine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
| ChEMBL | Inhibitory activity against cyclin-dependent kinase 1-cyclin B in starfish | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] | ||||||||
| GtoPdb | Measuring inhibition of CDK2 in association with cyclin E | - | 9.28 | pKi | 0.53 | nM | Ki | J Med Chem (2012) 55: 1926-39 [PMID:22289061] |
| ChEMBL | Inhibition of human recombinant CDK2/CycE using HHASPRK as substrate by ESI-MS analysis | B | 9.28 | pKi | 0.52 | nM | Ki | J Med Chem (2012) 55: 1926-1939 [PMID:22289061] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
| ChEMBL | Inhibitory activity against recombinant mammalian cyclin-dependent kinase 5 (p35 NCK5a) expressed in Escherichia coli | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of glycogen synthase kinase-3 beta, purified from porcine brain or expressed in and purified from insect Sf9 cells | B | 6.04 | pIC50 | 920 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
| protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289] | ||||||||
| GtoPdb | - | - | 6.03 | pKi | 933 | nM | Ki | J Med Chem (2012) 55: 1926-39 [PMID:22289061] |
| ChEMBL | Inhibition of human recombinant PYK2 by ESI-MS analysis | B | 6.03 | pKi | 933.25 | nM | Ki | J Med Chem (2012) 55: 1926-1939 [PMID:22289061] |
| zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
| ChEMBL | Inhibition of human recombinant ZAP70 using EEEEYEEEE as substrate by ESI-MS analysis | B | 5.58 | pKi | 2630.27 | nM | Ki | J Med Chem (2012) 55: 1926-1939 [PMID:22289061] |
| GtoPdb | - | - | 5.58 | pKi | 2630 | nM | Ki | J Med Chem (2012) 55: 1926-39 [PMID:22289061] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
