Akt inhibitor VIII [Ligand Id: 5921] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL258844 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| RuvB-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3259467] [UniProtKB: Q9Y265] | ||||||||
| ChEMBL | Inhibition of RUVBL1 (unknown origin) | B | 4.62 | pIC50 | 24000 | nM | IC50 | Bioorg Med Chem (2022) 62: 116726-116726 [PMID:35364523] |
| AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Inhibition of Akt1 by cell-based IPKA assay | B | 6.52 | pIC50 | 305 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| ChEMBL | Inhibition of Akt1 by cell-based assay | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3178-3182 [PMID:18479914] |
| ChEMBL | Inhibition of Akt1 | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| ChEMBL | Inhibition of human recombinant Akt1 | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2211-2214 [PMID:18296048] |
| ChEMBL | Inhibition of Akt1 | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3178-3182 [PMID:18479914] |
| ChEMBL | Inhibition of Akt1 | B | 7.24 | pIC50 | 58 | nM | IC50 | J Med Chem (2010) 53: 1413-1437 [PMID:20166671] |
| ChEMBL | Inhibitory concentration against Akt1 kinase | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 905-909 [PMID:15686884] |
| ChEMBL | Inhibition of Akt1 (unknown origin) | B | 7.24 | pIC50 | 58 | nM | IC50 | Eur J Med Chem (2016) 113: 214-227 [PMID:26945110] |
| ChEMBL | Inhibitory concentration against human Protein kinase B, alpha | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-764 [PMID:15664853] |
| GtoPdb | - | - | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-4 [PMID:15664853] |
| AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
| ChEMBL | Inhibitory concentration against Akt3 kinase | B | 5.66 | pIC50 | >2200 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 905-909 [PMID:15686884] |
| ChEMBL | Inhibition of Akt2 by cell-based IPKA assay | B | 5.68 | pIC50 | 2100 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| ChEMBL | Inhibition of Akt2 by cell-based assay | B | 6.05 | pIC50 | 900 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3178-3182 [PMID:18479914] |
| ChEMBL | Inhibition of Akt2 | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3178-3182 [PMID:18479914] |
| ChEMBL | Inhibition of Akt2 | B | 6.68 | pIC50 | 210 | nM | IC50 | J Med Chem (2010) 53: 1413-1437 [PMID:20166671] |
| ChEMBL | Inhibition of human recombinant Akt2 | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2211-2214 [PMID:18296048] |
| ChEMBL | Inhibitory concentration against human Protein kinase B, Akt2 | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-764 [PMID:15664853] |
| ChEMBL | Inhibition of Akt2 | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| GtoPdb | - | - | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-4 [PMID:15664853] |
| ChEMBL | Inhibition of Akt2 (unknown origin) | B | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2016) 113: 214-227 [PMID:26945110] |
| AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
| ChEMBL | Inhibition of Akt3 by cell-based IPKA assay | B | 5 | pIC50 | >=10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| ChEMBL | Inhibition of Akt3 | B | 5.66 | pIC50 | 2200 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| ChEMBL | Inhibition of Akt3 (unknown origin) | B | 5.66 | pIC50 | 2200 | nM | IC50 | Eur J Med Chem (2016) 113: 214-227 [PMID:26945110] |
| GtoPdb | - | - | 5.67 | pIC50 | 2119 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-4 [PMID:15664853] |
| ChEMBL | Inhibitory concentration against human Protein kinase B, Akt3 | B | 5.67 | pIC50 | 2119 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-764 [PMID:15664853] |
| ChEMBL | Inhibition of human recombinant Akt3 | B | 5.67 | pIC50 | >2119 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2211-2214 [PMID:18296048] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
