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ChEMBL ligand: CHEMBL76589 (Tyrphostin Ag-112) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
GtoPdb | Measuring inhibition of substrate phosphorylation. | - | 6.9 | pIC50 | 125 | nM | IC50 | J Med Chem (1989) 32: 2344-52 [PMID:2552117] |
ChEMBL | Inhibitory concentration of EGF dependent autophosphorylation of epidermal growth factor receptor kinase | B | 6.9 | pIC50 | 125 | nM | IC50 | J. Med. Chem. (1989) 32: 2344-2352 [PMID:2552117] |
ChEMBL | Inhibition of EGFR in human A431 cells | B | 7 | pIC50 | 100 | nM | IC50 | J. Nat. Prod. (1992) 55: 1529-1560 [PMID:1479375] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]