AG 112 [Ligand Id: 5913] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL76589 (Tyrphostin Ag-112)
  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb Measuring inhibition of substrate phosphorylation. - 6.9 pIC50 125 nM IC50 J Med Chem (1989) 32: 2344-52 [PMID:2552117]
ChEMBL Inhibitory concentration of EGF dependent autophosphorylation of epidermal growth factor receptor kinase B 6.9 pIC50 125 nM IC50 J. Med. Chem. (1989) 32: 2344-2352 [PMID:2552117]
ChEMBL Inhibition of EGFR in human A431 cells B 7 pIC50 100 nM IC50 J. Nat. Prod. (1992) 55: 1529-1560 [PMID:1479375]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]