L-692,429 [Ligand Id: 5868] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL308716 (L-692429)
Created with Highcharts 10.3.3ValuesChart context menuGhrelin receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd PigpKi PigpIC50 PigpEC50 PigpKd RatpKi RatpIC50 RatpEC50 Rat02468Highcharts.com
  • GHRH receptor/Growth hormone-releasing hormone receptor in Rat [ChEMBL: CHEMBL3709] [GtoPdb: 247] [UniProtKB: Q02644]
Created with Highcharts 10.3.3ValuesChart context menuGrowth hormone-releasing hormone receptorpKd RatpKi RatpIC50 RatpEC50 Rat02468Highcharts.com
  • AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
Created with Highcharts 10.3.3ValuesChart context menuType-1 angiotensin II receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847]
ChEMBL Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand B 7.2 pKi 63 nM Ki J Med Chem (1996) 39: 1767-1770 [PMID:8627599]
ChEMBL Inhibition against human growth hormone secretagogue (GHS) receptor B 5.55 pIC50 2800 nM IC50 J Med Chem (2004) 47: 888-899 [PMID:14761190]
GtoPdb - - 7 pEC50 100 nM EC50 Mol Endocrinol (2005) 19: 2400-11 [PMID:15905359]
GtoPdb - - 7.59 pEC50 26 nM EC50 Mol Endocrinol (2005) 19: 2400-11 [PMID:15905359]
Ghrelin receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2224] [UniProtKB: Q95254]
ChEMBL Inhibition against pig growth hormone secretagogue (GHS) receptor B 7.2 pIC50 63 nM IC50 J Med Chem (2004) 47: 888-899 [PMID:14761190]
ghrelin receptor/Ghrelin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3278] [GtoPdb: 246] [UniProtKB: O08725]
ChEMBL Inhibition against rat growth hormone secretagogue (GHS) receptor B 7.22 pIC50 60 nM IC50 J Med Chem (2004) 47: 888-899 [PMID:14761190]
GtoPdb - - 7.22 pEC50 60 nM EC50 Science (1993) 260: 1640-3 [PMID:8503009]
ChEMBL In vitro growth hormone release was determined in rat pituitary cell assay F 7.22 pEC50 60 nM EC50 Bioorg Med Chem Lett (1998) 8: 107-112 [PMID:9925440]
GHRH receptor/Growth hormone-releasing hormone receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3709] [GtoPdb: 247] [UniProtKB: Q02644]
ChEMBL Ability to release growth hormone in a rat pituitary cell assay F 7.22 pEC50 60 nM EC50 Bioorg Med Chem Lett (1997) 7: 2319-2324
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL Inhibition against human angiotensin II receptor, type 1 (AG2-R) B 5.44 pIC50 3600 nM IC50 J Med Chem (2004) 47: 888-899 [PMID:14761190]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]