L-692,429 [Ligand Id: 5868] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL308716 (L-692429) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847] | ||||||||
| ChEMBL | Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand | B | 7.2 | pKi | 63 | nM | Ki | J Med Chem (1996) 39: 1767-1770 [PMID:8627599] |
| ChEMBL | Inhibition against human growth hormone secretagogue (GHS) receptor | B | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (2004) 47: 888-899 [PMID:14761190] |
| GtoPdb | - | - | 7 | pEC50 | 100 | nM | EC50 | Mol Endocrinol (2005) 19: 2400-11 [PMID:15905359] |
| GtoPdb | - | - | 7.59 | pEC50 | 26 | nM | EC50 | Mol Endocrinol (2005) 19: 2400-11 [PMID:15905359] |
| Ghrelin receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2224] [UniProtKB: Q95254] | ||||||||
| ChEMBL | Inhibition against pig growth hormone secretagogue (GHS) receptor | B | 7.2 | pIC50 | 63 | nM | IC50 | J Med Chem (2004) 47: 888-899 [PMID:14761190] |
| ghrelin receptor/Ghrelin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3278] [GtoPdb: 246] [UniProtKB: O08725] | ||||||||
| ChEMBL | Inhibition against rat growth hormone secretagogue (GHS) receptor | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2004) 47: 888-899 [PMID:14761190] |
| GtoPdb | - | - | 7.22 | pEC50 | 60 | nM | EC50 | Science (1993) 260: 1640-3 [PMID:8503009] |
| ChEMBL | In vitro growth hormone release was determined in rat pituitary cell assay | F | 7.22 | pEC50 | 60 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 107-112 [PMID:9925440] |
| GHRH receptor/Growth hormone-releasing hormone receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3709] [GtoPdb: 247] [UniProtKB: Q02644] | ||||||||
| ChEMBL | Ability to release growth hormone in a rat pituitary cell assay | F | 7.22 | pEC50 | 60 | nM | EC50 | Bioorg Med Chem Lett (1997) 7: 2319-2324 |
| AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| ChEMBL | Inhibition against human angiotensin II receptor, type 1 (AG2-R) | B | 5.44 | pIC50 | 3600 | nM | IC50 | J Med Chem (2004) 47: 888-899 [PMID:14761190] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
