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ChEMBL ligand: CHEMBL275667 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
ChEMBL | Binding affinity towards DP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | B | 4.89 | pKi | >13000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927] |
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
ChEMBL | Binding affinity towards EP1 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | B | 4.89 | pKi | >13000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927] |
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
ChEMBL | Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | B | 4.89 | pKi | >13000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927] |
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
ChEMBL | Binding affinity towards EP3 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | B | 4.89 | pKi | >13000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927] |
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
GtoPdb | - | - | 8.92 | pKi | 1.2 | nM | Ki | Heterocycles (2004) 64: 437-446 |
ChEMBL | Binding affinity towards EP4 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | B | 8.92 | pKi | 1.2 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927] |
ChEMBL | Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927] |
ChEMBL | EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor | F | 8.6 | pEC50 | 2.5 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927] |
FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088] | ||||||||
ChEMBL | Binding affinity towards FP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | B | 4.89 | pKi | >13000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927] |
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
ChEMBL | Binding affinity towards IP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | B | 4.89 | pKi | >13000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927] |
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
ChEMBL | Binding affinity towards TP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | B | 4.89 | pKi | >13000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]