MF 498 [Ligand Id: 5856] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL402162 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| ChEMBL | Binding affinity to human DP receptor expressed in HEK293 cells | B | 5.92 | pKi | 1200 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| ChEMBL | Binding affinity to human EP1 receptor expressed in HEK293 cells | B | 5.15 | pKi | >7000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
| ChEMBL | Binding affinity to human EP2 receptor expressed in HEK293 cells | B | 5.72 | pKi | 1900 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
| ChEMBL | Binding affinity to human EP3 receptor expressed in HEK293 cells | B | 5.4 | pKi | 4000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| ChEMBL | Binding affinity to human EP4 receptor expressed in HEK293 cells in presence of 10% human serum | B | 8.44 | pKi | 3.6 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| ChEMBL | Binding affinity to human EP4 receptor expressed in HEK293 cells | B | 9.13 | pKi | 0.74 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| GtoPdb | - | - | 9.15 | pKi | 0.7 | nM | Ki | J Pharmacol Exp Ther (2008) 325: 425-34 [PMID:18287210] |
| FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088] | ||||||||
| ChEMBL | Binding affinity to human FP receptor expressed in HEK293 cells | B | 5.7 | pKi | 2000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
| ChEMBL | Binding affinity to human IP receptor expressed in HEK293 cells | B | 5.15 | pKi | >7000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
| TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| ChEMBL | Binding affinity to human TP receptor expressed in HEK293 cells | B | 6.2 | pKi | 630 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2048-2054 [PMID:18291643] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
