FK-788 [Ligand Id: 5855] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL196779 (FK-788)
  • DP1 receptor/Prostanoid DP receptor in Human [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
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  • EP1 receptor/Prostanoid EP1 receptor in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
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  • EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
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  • EP3 receptor/Prostanoid EP3 receptor in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
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  • EP4 receptor/Prostanoid EP4 receptor in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
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  • FP receptor/Prostanoid FP receptor in Human [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088]
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  • IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
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  • TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
ChEMBL Displacement of [3H]PGD-2 from human Prostanoid DP receptor B 5.64 pKi 2300 nM Ki Bioorg Med Chem Lett (2005) 15: 3091-3095 [PMID:15914004]
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL Displacement of [3H]PGE-2 from human Prostanoid EP1 receptor B 5.02 pKi 9600 nM Ki Bioorg Med Chem Lett (2005) 15: 3091-3095 [PMID:15914004]
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
ChEMBL Displacement of [3H]-PGE-2 from human Prostanoid EP2 receptor B 5 pKi >10000 nM Ki Bioorg Med Chem Lett (2005) 15: 3091-3095 [PMID:15914004]
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
ChEMBL Displacement of [3H]PGE-2 from human Prostanoid EP3 receptor B 5.09 pKi 8200 nM Ki Bioorg Med Chem Lett (2005) 15: 3091-3095 [PMID:15914004]
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
ChEMBL Displacement of [3H]PGE-2 from human Prostanoid EP4 receptor B 5 pKi >10000 nM Ki Bioorg Med Chem Lett (2005) 15: 3091-3095 [PMID:15914004]
FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088]
ChEMBL Displacement of [3H]PGF-2 from human Prostanoid FP receptor B 5 pKi >10000 nM Ki Bioorg Med Chem Lett (2005) 15: 3091-3095 [PMID:15914004]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
GtoPdb - - 8.05 pKi - - - Bioorg Med Chem Lett (2005) 15: 3091-5 [PMID:15914004]
ChEMBL Displacement of [3H]iloprost from human Prostanoid IP receptor B 8.05 pKi 8.9 nM Ki Bioorg Med Chem Lett (2005) 15: 3091-3095 [PMID:15914004]
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL Displacement of [3H]SQ-29,548 from human Prostanoid TP receptor B 5 pKi >10000 nM Ki Bioorg Med Chem Lett (2005) 15: 3091-3095 [PMID:15914004]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]