treprostinil [Ligand Id: 5820] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1237119 (15-AU-81, 15AU81, L-606, LRX -15, LRX-15, Remodulin, Rumodolin, Treprostinil, Tresprostinil, Tyvaso, Tyvaso dpi, Uniprost, UT-15) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | - | - | - |
Biochem Pharmacol (2012) 84: 68-75 [PMID:22480736]; Prostaglandins Leukot Essent Fatty Acids (2015) 95: 19-29 [PMID:25542069] |
| EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| GtoPdb | - | - | 6.7 | pKi | - | - | - | Biochem Pharmacol (2012) 84: 68-75 [PMID:22480736] |
| EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | - | - | - |
Biochem Pharmacol (2012) 84: 68-75 [PMID:22480736]; Prostaglandins Leukot Essent Fatty Acids (2015) 95: 19-29 [PMID:25542069] |
| EP3 receptor in Human [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
| GtoPdb | - | - | 5.6 | pKi | 2500 | nM | Ki | Biochem Pharmacol (2012) 84: 68-75 [PMID:22480736] |
| EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| GtoPdb | - | - | 6.1 | pKi | 800 | nM | Ki | Biochem Pharmacol (2012) 84: 68-75 [PMID:22480736] |
| GtoPdb | - | - | 6.7 | pEC50 | 200 | nM | EC50 | Biochem Pharmacol (2012) 84: 68-75 [PMID:22480736] |
| IP receptor in Human [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
| GtoPdb | - | - | 7.49 | pKi | - | - | - | Biochem Pharmacol (2012) 84: 68-75 [PMID:22480736] |
| GtoPdb | - | - | 8.72 | pEC50 | - | - | - |
Biochem Pharmacol (2012) 84: 68-75 [PMID:22480736]; N Engl J Med (2021) 384: 325-334 [PMID:33440084] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
