ChEMBL ligand: CHEMBL1210313
NPS receptor/Neuropeptide S receptor in Human [ChEMBL: CHEMBL5162] [GtoPdb: 302] [UniProtKB: Q6W5P4] NPS receptor/Neuropeptide S receptor in Rat [ChEMBL: CHEMBL3308949] [GtoPdb: 302] [UniProtKB: P0C0L6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
NPS receptor/Neuropeptide S receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5162] [GtoPdb: 302] [UniProtKB: Q6W5P4]
ChEMBL	Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay	F	6.11	pIC50	785	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]
ChEMBL	Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay	F	7.26	pIC50	55	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
ChEMBL	Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay	F	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]
ChEMBL	Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay	B	7.96	pIC50	11	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
GtoPdb	-	-	8	pIC50	-	-	-	Bioorg Med Chem Lett (2010) 20: 4700-3 [PMID:20510609]
ChEMBL	Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay	F	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]
ChEMBL	Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay	F	8	pIC50	10	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
ChEMBL	Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting	B	8.17	pIC50	6.7	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
ChEMBL	Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
ChEMBL	Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay	F	8.92	pIC50	1.2	nM	IC50	J Med Chem (2013) 56: 9045-9056 [PMID:24171469]
NPS receptor/Neuropeptide S receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308949] [GtoPdb: 302] [UniProtKB: P0C0L6]
ChEMBL	Displacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 mins	B	5.84	pIC50	1440	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]
ChEMBL	Displacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 mins	B	5.85	pEC50	1400	nM	EC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]
ChEMBL	Displacement of [3H]quinolinone from rat NPS receptor	B	8.89	pEC50	1.3	nM	EC50	Bioorg Med Chem Lett (2010) 20: 4700-4703 [PMID:20510609]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]