vofopitant [Ligand Id: 5752] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL522302 (Gr-205171, GR-205171, GR205171, Vofopitant) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| ChEMBL | Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells | B | 10.3 | pKi | 0.05 | nM | Ki | J Med Chem (2009) 52: 3238-3247 [PMID:19388677] |
| GtoPdb | - | - | 10.6 | pKi | - | - | Ki | Regul Pept (1996) 65: 45-53 [PMID:8876035] |
| ChEMBL | Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells | B | 10.1 | pIC50 | 0.08 | nM | IC50 | J Med Chem (1998) 41: 4607-4614 [PMID:9804700] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
