compound 58 [PMID: 21273063] [Ligand Id: 5748] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1771100 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GPR119/Glucose-dependent insulinotropic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5652] [GtoPdb: 126] [UniProtKB: Q8TDV5] | ||||||||
| ChEMBL | Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay | F | 8.4 | pEC50 | 4 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 2665-2669 [PMID:21273063] |
| GtoPdb | - | - | 8.4 | pEC50 | 4 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 2665-9 [PMID:21273063] |
| GPR119/Glucose-dependent insulinotropic receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5263] [GtoPdb: 126] [UniProtKB: Q7TQP3] | ||||||||
| ChEMBL | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay | F | 8.4 | pEC50 | 4 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 2665-2669 [PMID:21273063] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG by patch clamp technique | B | 4.72 | pIC50 | 19000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2665-2669 [PMID:21273063] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
