CPFPX [Ligand Id: 5603] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2311146
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
  • Adenosine A1 receptor in Bovine [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
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  • A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
  • A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL In vitro binding affinity for porcine Adenosine A1 receptor B 8.86 pKd 1.37 nM Kd J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
ChEMBL In vitro binding affinity for human Adenosine A1 receptor expressed in CHO-K1 cells B 8.9 pKd 1.26 nM Kd J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
GtoPdb - - 8.9 pKi 1.26 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
ChEMBL In vitro binding affinity for Adenosine A1 receptor of bovine cortex B 9.74 pKi 0.18 nM Ki J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL In vitro binding affinity at rat Adenosine A1 receptor B 9.2 pKd 0.63 nM Kd J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
GtoPdb - - 9.2 pKi 0.63 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
GtoPdb - - 6.03 pKi 940 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
GtoPdb - - 6.09 pKi 812 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
ChEMBL In vitro binding affinity at Adenosine A2A receptor of rat cortex B 6.09 pKi 812 nM Ki J Med Chem (2002) 45: 5150-5156 [PMID:12408725]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]