2-arachidonyl glyceryl ether [Ligand Id: 5545] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL146346 (HU-310)
  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
  • CB1 receptor/Cannabinoid CB1 receptor in Rat [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272]
Created with Highcharts 10.3.3ValuesChart context menuCannabinoid CB1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat0246810Highcharts.com
  • CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
Created with Highcharts 10.3.3ValuesChart context menuCannabinoid CB2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6]
Created with Highcharts 10.3.3ValuesChart context menuGPR55pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Displacement of [3H]-CP55940 from human CB1 receptor expressed in HEK-293-EBNA cell membranes after 90 mins by scintillation counting B 7.6 pKi 25 nM Ki J Med Chem (2011) 54: 5265-5269 [PMID:21675776]
ChEMBL Displacement of [3H]CP55940 from human CB1 receptor expressed in human HEK293 cells B 7.7 pKi 20 nM Ki J Med Chem (2011) 54: 8278-8288 [PMID:22044209]
CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272]
ChEMBL Binding affinity for cannabinoid receptor 1 B 7.68 pKi 21 nM Ki J Med Chem (2005) 48: 5059-5087 [PMID:16078824]
ChEMBL Displacement of [3H]HU-243 from CB1 receptor of rat brain synaptosomal membranes B 7.68 pKi 21 nM Ki J Med Chem (2013) 56: 8224-8256 [PMID:23865723]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL Displacement of [3H]CP55940 from human CB2 receptor expressed in human HEK293 cells B 5.52 pKi >3000 nM Ki J Med Chem (2011) 54: 8278-8288 [PMID:22044209]
ChEMBL Binding affinity to human CB2 receptor B 5.52 pKi 3000 nM Ki J Med Chem (2013) 56: 8224-8256 [PMID:23865723]
ChEMBL Displacement of [3H]-CP55940 from human CB2 receptor expressed in HEK-293-EBNA cell membranes after 90 mins by scintillation counting B 6 pKi >1000 nM Ki J Med Chem (2011) 54: 5265-5269 [PMID:21675776]
GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6]
GtoPdb - - 8 pEC50 10 nM EC50 Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]