ChEMBL ligand: CHEMBL333985
Hypoxia-inducible factor 1 alpha in Human [ChEMBL: CHEMBL4261] [UniProtKB: Q16665] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Hypoxia-inducible factor 1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4261] [UniProtKB: Q16665]
ChEMBL	Inhibition of hypoxia induced HIF1-alpha transcriptional activity in human Sk-Hep1 cells by reporter gene assay	B	4.52	pIC50	>30000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6305-6310 [PMID:17884495]
ChEMBL	Inhibition of hypoxia induced HIF1-alpha transcriptional activity in human Hep3B cells by reporter gene assay	B	4.86	pIC50	13800	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6305-6310 [PMID:17884495]
ChEMBL	Inhibition of hypoxia-induced HIF1alpha transcriptional activity in HEK293 cells incubated for 16 hrs by hypoxia response element-driven luciferase reporter gene assay	B	5.04	pIC50	9210	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3166-3169 [PMID:19435661]
ChEMBL	Inhibition of HIF1alpha transcriptional activity in human HeLa cells transfected with HRE-firefly luciferase and cytomegalovirus-promoter expressing Renilla luciferase incubated for 12 hrs under 1% O2 condition by dual luciferase reporter gene assay	B	5.62	pIC50	2400	nM	IC50	Bioorg Med Chem (2020) 28: 115207-115207 [PMID:31740202]
ChEMBL	Inhibition of hypoxia induced HIF1-alpha transcriptional activity in human AGS cells by reporter gene assay	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6305-6310 [PMID:17884495]
ChEMBL	Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assay	B	5.82	pIC50	1500	nM	IC50	ACS Med Chem Lett (2013) 4: 297-301 [PMID:24900662]
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL	Inhibition of PDE5 from platelets	B	4.5	pIC50	31900	nM	IC50	J Med Chem (2001) 44: 3746-3749 [PMID:11606139]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5.2	pIC50	6309.57	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]