SCH51866 [Ligand Id: 5270] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1628659 (SCH-51866) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] | ||||||||
| GtoPdb | - | - | 7.2 | pIC50 | 63.1 | nM | IC50 | J Cardiovasc Pharmacol (1996) 28: 862-9 [PMID:8961086] |
| ChEMBL | Inhibition of PDE5 (unknown origin) | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2017) 60: 3472-3483 [PMID:28406621] |
| phosphodiesterase 1A in Human [GtoPdb: 1294] [UniProtKB: P54750] | ||||||||
| GtoPdb | - | - | 7.2 | pIC50 | 63.1 | nM | IC50 | J Cardiovasc Pharmacol (1996) 28: 862-9 [PMID:8961086] |
| phosphodiesterase 1B in Human [GtoPdb: 1295] [UniProtKB: Q01064] | ||||||||
| GtoPdb | - | - | 7.2 | pIC50 | 63.1 | nM | IC50 | J Cardiovasc Pharmacol (1996) 28: 862-9 [PMID:8961086] |
| phosphodiesterase 1C in Human [GtoPdb: 1296] [UniProtKB: Q14123] | ||||||||
| GtoPdb | - | - | 7.2 | pIC50 | 63.1 | nM | IC50 | J Cardiovasc Pharmacol (1996) 28: 862-9 [PMID:8961086] |
| phosphodiesterase 7B in Human [GtoPdb: 1306] [UniProtKB: Q9NP56] | ||||||||
| GtoPdb | - | - | 5.8 | pIC50 | 1580 | nM | IC50 | Biochem Biophys Res Commun (2000) 271: 575-83 [PMID:10814504] |
| phosphodiesterase 9A in Human [GtoPdb: 1309] [UniProtKB: O76083] | ||||||||
| GtoPdb | - | - | 5.8 | pIC50 | 1580 | nM | IC50 | J Biol Chem (1998) 273: 15559-64 [PMID:9624146] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
