ChEMBL ligand: CHEMBL18701 (Ro-201724)
phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
TNF-alpha in Human [ChEMBL: CHEMBL1825] [UniProtKB: P01375] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL	Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay	B	5.37	pIC50	4300	nM	IC50	J Med Chem (2011) 54: 3331-3347 [PMID:21456625]
GtoPdb	-	-	6.5	pIC50	316	nM	IC50	Biochem Biophys Res Commun (1997) 234: 320-4 [PMID:9177268]
ChEMBL	Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci	B	5.48	pEC50	3300	nM	EC50	J Med Chem (2011) 54: 3331-3347 [PMID:21456625]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of human Phosphodiesterase 4B	B	5.71	pKi	1930	nM	Ki	J Med Chem (1995) 38: 4848-4854 [PMID:7490734]
GtoPdb	-	-	6.4	pIC50	398	nM	IC50	Biochem Biophys Res Commun (1997) 234: 320-4 [PMID:9177268]
TNF-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1825] [UniProtKB: P01375]
ChEMBL	TNF-alpha production in PBMC by ELISA method	F	4.3	pIC50	50000	nM	IC50	J Med Chem (1996) 39: 2-9 [PMID:8568809]
phosphodiesterase 4C in Human [GtoPdb: 1302] [UniProtKB: Q08493]
GtoPdb	-	-	5.4	pIC50	3980	nM	IC50	Biochem Biophys Res Commun (1997) 234: 320-4 [PMID:9177268]
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
GtoPdb	-	-	6.2	pIC50	631	nM	IC50	Biochem Biophys Res Commun (1997) 234: 320-4 [PMID:9177268]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]