Gö 6983 [Ligand Id: 5192] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL261491 (Go-6893)
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  • protein kinase C alpha in Human [GtoPdb: 1482] [UniProtKB: P17252]
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  • protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771]
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  • protein kinase C gamma in Human [GtoPdb: 1484] [UniProtKB: P05129]
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  • protein kinase C delta in Human [GtoPdb: 1485] [UniProtKB: Q05655]
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  • protein kinase C zeta in Human [GtoPdb: 1491] [UniProtKB: Q05513]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
L-type calcium channel alpha 1C/beta 2A in Rabbit (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3638171] [UniProtKB: P15381P54288]
ChEMBL Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in human HEK293 cells transfected with rabbit L-type calcium channel subunits F 4.7 pIC50 20000 nM IC50 IC50 data for the L-type calcium channel extracted from a set of literature articles
protein kinase C alpha in Human [GtoPdb: 1482] [UniProtKB: P17252]
GtoPdb - - 8.15 pIC50 7 nM IC50 FEBS Lett (1996) 392: 77-80 [PMID:8772178]
protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771]
GtoPdb - - 8.15 pIC50 7 nM IC50 FEBS Lett (1996) 392: 77-80 [PMID:8772178]
protein kinase C gamma in Human [GtoPdb: 1484] [UniProtKB: P05129]
GtoPdb - - 8.22 pIC50 6 nM IC50 FEBS Lett (1996) 392: 77-80 [PMID:8772178]
protein kinase C delta in Human [GtoPdb: 1485] [UniProtKB: Q05655]
GtoPdb - - 8 pIC50 10 nM IC50 FEBS Lett (1996) 392: 77-80 [PMID:8772178]
protein kinase C zeta in Human [GtoPdb: 1491] [UniProtKB: Q05513]
GtoPdb - - 7.22 pIC50 60 nM IC50 FEBS Lett (1996) 392: 77-80 [PMID:8772178]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]