forskolin [Ligand Id: 5190] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL52606 (Boforsin, Colforsin, Forskolin, HL 362, HL-362, L 75 1362B, L-75-1362B, L-751362B, NSC-357088, NSC-375489) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Adenylate cyclase type I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3549] [UniProtKB: P19754] | ||||||||
| ChEMBL | Displacement of [125I]6-IHPP-Fsk from adenylate cyclase of bovine brain membrane | B | 7.54 | pKd | 29 | nM | Kd | J Med Chem (1991) 34: 3204-3212 [PMID:1956039] |
| adenylyl cyclase 2/Adenylate cyclase type II in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2958] [GtoPdb: 1279] [UniProtKB: P26769] | ||||||||
| ChEMBL | Ability to activate the conversion of [32P] ATP to [32P]-cyclic AMP | F | 5.7 | pEC50 | <2000 | nM | EC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| adenylyl cyclase 8/Adenylate cyclase type VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2960] [GtoPdb: 1285] [UniProtKB: P40145] | ||||||||
| ChEMBL | Agonist activity at recombinant human AC8 expressed in human HEK293 cells assessed as fold increase in cAMP level by LANCE Ultra cAMP Detection kit method | B | 7.03 | pEC50 | 93.7 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 126823-126823 [PMID:31776060] |
| adenylyl cyclase 1/Brain adenylate cyclase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2899] [GtoPdb: 1278] [UniProtKB: Q08828] | ||||||||
| ChEMBL | Inhibition of [125 I]6-IHPP-forskolin binding to Adenylate cyclase 1 | B | 6.82 | pIC50 | <150 | nM | IC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| ChEMBL | Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 | B | 7.39 | pIC50 | 41 | nM | IC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| ChEMBL | Conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 | F | 6.3 | pEC50 | 500 | nM | EC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| Glucose transporter 1/Glucose transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2535] [GtoPdb: 875] [UniProtKB: P11166] | ||||||||
| ChEMBL | Inhibition of [125I]7-IHPP-Fsk binding to glucose transporter of human erythrocyte membrane | B | 5.3 | pKd | 5000 | nM | Kd | J Med Chem (1991) 34: 3204-3212 [PMID:1956039] |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells | F | 4.1 | pIC50 | 80200 | nM | IC50 | Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514] |
| RXFP1/Relaxin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293316] [GtoPdb: 351] [UniProtKB: Q9HBX9] | ||||||||
| ChEMBL | Agonist activity at human RXFP1 expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay | F | 7.33 | pEC50 | 47 | nM | EC50 | Eur J Med Chem (2018) 156: 79-92 [PMID:30006176] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
