forskolin [Ligand Id: 5190] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL52606 (Boforsin, Colforsin, Forskolin, HL 362, HL-362, L 75 1362B, L-75-1362B, L-751362B, NSC-357088, NSC-375489) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Adenylate cyclase type I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3549] [UniProtKB: P19754] | ||||||||
| ChEMBL | Displacement of [125I]6-IHPP-Fsk from adenylate cyclase of bovine brain membrane | B | 7.54 | pKd | 29 | nM | Kd | J Med Chem (1991) 34: 3204-3212 [PMID:1956039] |
| adenylyl cyclase 2/Adenylate cyclase type II in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2958] [GtoPdb: 1279] [UniProtKB: P26769] | ||||||||
| ChEMBL | Ability to activate the conversion of [32P] ATP to [32P]-cyclic AMP | F | 5.7 | pEC50 | <2000 | nM | EC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| adenylyl cyclase 8/Adenylate cyclase type VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2960] [GtoPdb: 1285] [UniProtKB: P40145] | ||||||||
| ChEMBL | Agonist activity at recombinant human AC8 expressed in human HEK293 cells assessed as fold increase in cAMP level by LANCE Ultra cAMP Detection kit method | B | 7.03 | pEC50 | 93.7 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 126823-126823 [PMID:31776060] |
| adenylyl cyclase 1/Brain adenylate cyclase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2899] [GtoPdb: 1278] [UniProtKB: Q08828] | ||||||||
| ChEMBL | Inhibition of [125 I]6-IHPP-forskolin binding to Adenylate cyclase 1 | B | 6.82 | pIC50 | <150 | nM | IC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| ChEMBL | Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 | B | 7.39 | pIC50 | 41 | nM | IC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| ChEMBL | Conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 | F | 6.3 | pEC50 | 500 | nM | EC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| Glucose transporter 1/Glucose transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2535] [GtoPdb: 875] [UniProtKB: P11166] | ||||||||
| ChEMBL | Inhibition of [125I]7-IHPP-Fsk binding to glucose transporter of human erythrocyte membrane | B | 5.3 | pKd | 5000 | nM | Kd | J Med Chem (1991) 34: 3204-3212 [PMID:1956039] |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells | F | 4.1 | pIC50 | 80200 | nM | IC50 | Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514] |
| RXFP1/Relaxin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293316] [GtoPdb: 351] [UniProtKB: Q9HBX9] | ||||||||
| ChEMBL | Agonist activity at human RXFP1 expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay | F | 7.33 | pEC50 | 47 | nM | EC50 | Eur J Med Chem (2018) 156: 79-92 [PMID:30006176] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
