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ChEMBL ligand: CHEMBL190662 (Cyclohexanecarboxylic Acid Pentadecylamide, N-Pentadecylcyclohexanecarboxamide) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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N-Acylethanolamine acid amidase/N-acylsphingosine-amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4349] [GtoPdb: 1402] [UniProtKB: Q02083] | ||||||||
ChEMBL | Inhibition of human recombinant NAAA expressed in human HEK293 cells assessed as conversion of [1,2-14C]palmitoylethanolamine to [1,2-14C]ethanolamine by liquid scintillation counting | B | 4.77 | pIC50 | 17000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1210-1213 [PMID:20022504] |
GtoPdb | - | - | 5.3 | pIC50 | 5010 | nM | IC50 | Biochem J (2004) 379: 99-106 [PMID:14686878] |
ChEMBL | Inhibitory concentration against N-palmitoylethanolamine acid amidase | B | 5.35 | pIC50 | 4500 | nM | IC50 | J Med Chem (2005) 48: 5059-5087 [PMID:16078824] |
ChEMBL | Inhibition of NAAA | B | 5.35 | pIC50 | 4500 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1210-1213 [PMID:20022504] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]