AZ10417808 [Ligand Id: 5143] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL586058
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  • Caspase 3 in Human [GtoPdb: 1619] [UniProtKB: P42574]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779]
ChEMBL Inhibition of Trypanosoma cruzi cruzain by quantitative high throughput screening B 4.22 pIC50 >60000 nM IC50 J Med Chem (2010) 53: 37-51 [PMID:19908840]
Caspase 3 in Human [GtoPdb: 1619] [UniProtKB: P42574]
GtoPdb - - 6.61 pKi 247 nM Ki J Pharmacol Exp Ther (2003) 304: 433-40 [PMID:12490620]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]