3-deazaadenosine [Ligand Id: 5115] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL202701 (3-Deazaadenosine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand. | B | 4.67 | pKi | 21500 | nM | Ki | J Med Chem (1995) 38: 1174-1188 [PMID:7707320] |
| A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
| ChEMBL | Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand | B | 4.22 | pKi | 59800 | nM | Ki | J Med Chem (1995) 38: 1174-1188 [PMID:7707320] |
| A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
| ChEMBL | Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat adenosine A3 receptor | B | 4.21 | pKi | 61700 | nM | Ki | J Med Chem (1995) 38: 1174-1188 [PMID:7707320] |
| S-Adenosylhomocysteine hydrolase/Adenosylhomocysteinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2664] [GtoPdb: 1233] [UniProtKB: P23526] | ||||||||
| ChEMBL | Inhibition of SAH hydrolase (unknown origin) | B | 5.27 | pIC50 | 5390 | nM | IC50 | Bioorg Med Chem Lett (2022) 72: 128880-128880 [PMID:35809817] |
| ChEMBL | Inhibitory activity against S-adenosyl-homocysteine hydrolase | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (1982) 25: 96-98 [PMID:6283083] |
| GtoPdb | - | - | 8.5 | pIC50 | 3.16 | nM | IC50 | Biochemistry (1981) 20: 110-5 [PMID:7470463] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 5.6 | pIC50 | 2511.89 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.7 | pIC50 | 1995.26 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
