ChEMBL ligand: CHEMBL40833
Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] Neuronal NOS/Nitric-oxide synthase, brain in Rat [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] There should be some charts here, you may need to enable JavaScript!
Endothelial NOS/Nitric-oxide synthase, endothelial in Human [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] There should be some charts here, you may need to enable JavaScript!
Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
ChEMBL	Inhibition of human nNOS	B	6.8	pIC50	160	nM	IC50	Nat Chem Biol (2008) 4: 700-707 [PMID:18849972]
ChEMBL	In vitro inhibition of human neuronal nitric oxide synthase.	B	6.96	pIC50	110	nM	IC50	J Med Chem (2004) 47: 3320-3323 [PMID:15163211]
ChEMBL	Inhibitory activity against neuronal nitric oxide synthase	B	7.12	pIC50	75	nM	IC50	Bioorg Med Chem Lett (2000) 10: 1975-1978 [PMID:10987430]
ChEMBL	In vitro inhibition of human neuronal nitric oxide synthase	B	7.4	pIC50	40	nM	IC50	J Med Chem (2004) 47: 1575-1586 [PMID:14998342]
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
ChEMBL	In vitro inhibition of rat neuronal nitric oxide synthase	B	7.4	pIC50	40	nM	IC50	J Med Chem (2004) 47: 1575-1586 [PMID:14998342]
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
ChEMBL	Inhibition of human eNOS	B	6.49	pIC50	320	nM	IC50	Nat Chem Biol (2008) 4: 700-707 [PMID:18849972]
ChEMBL	In vitro inhibition of human endothelial nitric oxide synthase.	B	6.52	pIC50	300	nM	IC50	J Med Chem (2004) 47: 3320-3323 [PMID:15163211]
ChEMBL	In vitro inhibition of human endothelial nitric oxide synthase	B	7	pIC50	100	nM	IC50	J Med Chem (2004) 47: 1575-1586 [PMID:14998342]
ChEMBL	Inhibitory activity against endothelial nitric oxide synthase (eNOS)	B	7.14	pIC50	72	nM	IC50	Bioorg Med Chem Lett (2000) 10: 1975-1978 [PMID:10987430]
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
ChEMBL	Inhibitory activity against inducible nitric oxide synthase (iNOS)	B	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2000) 10: 1975-1978 [PMID:10987430]
ChEMBL	In vitro inhibition of human Inducible nitric oxide synthase.	B	6.92	pIC50	120	nM	IC50	J Med Chem (2004) 47: 3320-3323 [PMID:15163211]
ChEMBL	Inhibition of human iNOS	B	6.92	pIC50	120	nM	IC50	Nat Chem Biol (2008) 4: 700-707 [PMID:18849972]
GtoPdb	-	-	7.4	pIC50	39.8	nM	IC50	Br J Pharmacol (1996) 119: 1101-8 [PMID:8937711]
ChEMBL	In vitro inhibition of human inducible nitric oxide synthase	B	8	pIC50	10	nM	IC50	J Med Chem (2004) 47: 1575-1586 [PMID:14998342]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]