ChEMBL ligand: CHEMBL40833
Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] Neuronal NOS/Nitric-oxide synthase, brain in Rat [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] There should be some charts here, you may need to enable JavaScript!
Endothelial NOS/Nitric-oxide synthase, endothelial in Human [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] There should be some charts here, you may need to enable JavaScript!
Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
ChEMBL	Inhibition of human nNOS	B	6.8	pIC50	160	nM	IC50	Nat Chem Biol (2008) 4: 700-707 [PMID:18849972]
ChEMBL	In vitro inhibition of human neuronal nitric oxide synthase.	B	6.96	pIC50	110	nM	IC50	J Med Chem (2004) 47: 3320-3323 [PMID:15163211]
ChEMBL	Inhibitory activity against neuronal nitric oxide synthase	B	7.12	pIC50	75	nM	IC50	Bioorg Med Chem Lett (2000) 10: 1975-1978 [PMID:10987430]
ChEMBL	In vitro inhibition of human neuronal nitric oxide synthase	B	7.4	pIC50	40	nM	IC50	J Med Chem (2004) 47: 1575-1586 [PMID:14998342]
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
ChEMBL	In vitro inhibition of rat neuronal nitric oxide synthase	B	7.4	pIC50	40	nM	IC50	J Med Chem (2004) 47: 1575-1586 [PMID:14998342]
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
ChEMBL	Inhibition of human eNOS	B	6.49	pIC50	320	nM	IC50	Nat Chem Biol (2008) 4: 700-707 [PMID:18849972]
ChEMBL	In vitro inhibition of human endothelial nitric oxide synthase.	B	6.52	pIC50	300	nM	IC50	J Med Chem (2004) 47: 3320-3323 [PMID:15163211]
ChEMBL	In vitro inhibition of human endothelial nitric oxide synthase	B	7	pIC50	100	nM	IC50	J Med Chem (2004) 47: 1575-1586 [PMID:14998342]
ChEMBL	Inhibitory activity against endothelial nitric oxide synthase (eNOS)	B	7.14	pIC50	72	nM	IC50	Bioorg Med Chem Lett (2000) 10: 1975-1978 [PMID:10987430]
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
ChEMBL	Inhibitory activity against inducible nitric oxide synthase (iNOS)	B	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2000) 10: 1975-1978 [PMID:10987430]
ChEMBL	In vitro inhibition of human Inducible nitric oxide synthase.	B	6.92	pIC50	120	nM	IC50	J Med Chem (2004) 47: 3320-3323 [PMID:15163211]
ChEMBL	Inhibition of human iNOS	B	6.92	pIC50	120	nM	IC50	Nat Chem Biol (2008) 4: 700-707 [PMID:18849972]
GtoPdb	-	-	7.4	pIC50	39.8	nM	IC50	Br J Pharmacol (1996) 119: 1101-8 [PMID:8937711]
ChEMBL	In vitro inhibition of human inducible nitric oxide synthase	B	8	pIC50	10	nM	IC50	J Med Chem (2004) 47: 1575-1586 [PMID:14998342]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]