ChEMBL ligand: CHEMBL1282 (Aldara, Imiquimod, NSC-369100, NSC-759651, R-837, S-26308, S26308, Tmx-101, Zyclara)
7,8-dihydro-8-oxoguanine triphosphatase in Human [ChEMBL: CHEMBL3708265] [UniProtKB: P36639] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] There should be some charts here, you may need to enable JavaScript!
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] There should be some charts here, you may need to enable JavaScript!
H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021] There should be some charts here, you may need to enable JavaScript!
TLR7/Toll-like receptor 7 in Human [ChEMBL: CHEMBL5936] [GtoPdb: 1757] [UniProtKB: Q9NYK1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
7,8-dihydro-8-oxoguanine triphosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3708265] [UniProtKB: P36639]
ChEMBL	Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins by PPiLight detection reagent based luminescence assay	B	6.19	pIC50	646	nM	IC50	J Med Chem (2016) 59: 2346-2361 [PMID:26878898]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA)	B	5.52	pKi	2987	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA)	B	5.27	pIC50	5320	nM	IC50	DrugMatrix in vitro pharmacology data
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL	DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)	B	5.89	pKi	1288	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)	B	5.58	pIC50	2621	nM	IC50	DrugMatrix in vitro pharmacology data
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL	DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)	B	5.83	pKi	1481	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)	B	5.82	pIC50	1506	nM	IC50	DrugMatrix in vitro pharmacology data
TLR7/Toll-like receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5936] [GtoPdb: 1757] [UniProtKB: Q9NYK1]
ChEMBL	Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay	F	4.92	pEC50	12100	nM	EC50	ACS Med Chem Lett (2012) 3: 501-504 [PMID:22837811]
GtoPdb	-	-	4.94	pEC50	11400	nM	EC50	ACS Med Chem Lett (2017) 8: 1148-1152 [PMID:29152046]
ChEMBL	Agonist activity at human TLR7 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assay	B	4.94	pEC50	11400	nM	EC50	ACS Med Chem Lett (2017) 8: 1148-1152 [PMID:29152046]
ChEMBL	Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay	B	4.97	pEC50	10700	nM	EC50	J Med Chem (2014) 57: 339-347 [PMID:24383475]
ChEMBL	Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP reporter gene-based UV-vis absorbance method	B	5.17	pEC50	6800	nM	EC50	Bioorg Med Chem Lett (2020) 30: 126788-126788 [PMID:31784317]
ChEMBL	Agonist activity at human TLR7 in HEK293 cells cotransfected with SEAP reporter gene assessed as activity of SEAP incubated for 24 hrs by quanti-blue staining based SEAP reporter gene assay	B	5.21	pEC50	6200	nM	EC50	Eur J Med Chem (2019) 179: 109-122 [PMID:31247373]
ChEMBL	Agonist activity at human TLR7	B	5.66	pEC50	2210	nM	EC50	J Med Chem (2021) 64: 8010-8041 [PMID:34107682]
ChEMBL	Agonist activity at TLR7 (unknown origin)	B	5.67	pEC50	2120	nM	EC50	J Med Chem (2023) 66: 6437-6462 [PMID:37163340]
ChEMBL	Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay	F	5.67	pEC50	2120	nM	EC50	J Med Chem (2010) 53: 4450-4465 [PMID:20481492]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]