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ChEMBL ligand: CHEMBL184 (Aciclovir, Aciclovirum, Acycloguanosine, Acyclovir, Avaclyr, Avert, Aviral, Clearsore, Cyclovir, Cymex ultra, Duvimex, Gerpevir, Herpetad, Lipsore, Lypsyl, Novirus, NSC-645011, NSC-758477, Ranovir, Sitavig, Soothelip, Soraway, Viralief, Virasorb, Virovir 200, Virovir 400, Virovir 800, Zovirax) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Purine nucleoside phosphorylase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169594] [UniProtKB: P9WP01] | ||||||||
ChEMBL | Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysis | B | 4.9 | pKd | 12589.25 | nM | Kd | Bioorg. Med. Chem. (2010) 18: 4769-4774 [PMID:20570524] |
purine nucleoside phosphorylase/Purine nucleoside phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4338] [GtoPdb: 2841] [UniProtKB: P00491] | ||||||||
ChEMBL | Inhibition of human PNP | B | 4.04 | pKi | 91000 | nM | Ki | MedChemComm (2018) 9: 1983-1993 [PMID:30627387] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]