fenoprofen [Ligand Id: 4820] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1297 (53858, Fenoprofen, LILLY-53858, Nalfon, NSC-757813, Progesic)
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • SMCT1 in Human [GtoPdb: 922] [UniProtKB: Q8N695]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) B 6.84 pIC50 145 nM IC50 DrugMatrix in vitro pharmacology data
GtoPdb - - 6.84 pIC50 145 nM IC50 National Toxicology Program: Dept of Health and Human Services.. DrugMatrix
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassay B 4.58 pIC50 26300 nM IC50 Bioorg Med Chem (2018) 26: 4113-4126 [PMID:29980364]
SMCT1 in Human [GtoPdb: 922] [UniProtKB: Q8N695]
GtoPdb - - 4.57 pIC50 27000 nM IC50 Pharm Res (2006) 23: 1209-16 [PMID:16729224]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]