ChEMBL ligand: CHEMBL1568 (2-Fluoro-Ara-A, Fludarabine)
Ecto-5'-Nucleotidase/5`-nucleotidase in Human [ChEMBL: CHEMBL5957] [GtoPdb: 1232] [UniProtKB: P21589] There should be some charts here, you may need to enable JavaScript!
A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] There should be some charts here, you may need to enable JavaScript!
ribonucleotide reductase catalytic subunit M1 in Human [GtoPdb: 2630] [UniProtKB: P23921] There should be some charts here, you may need to enable JavaScript!
ribonucleotide reductase regulatory subunit M2 in Human [GtoPdb: 2631] [UniProtKB: P31350] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Ecto-5'-Nucleotidase/5`-nucleotidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5957] [GtoPdb: 1232] [UniProtKB: P21589]
ChEMBL	Non-competitive type of inhibition of human 5'-nucleotidase using IMP as substrate assessed as inhibitor constant for enzyme substrate complex by Lineweaver-Burk plot analysis	B	3.05	pKi	900000	nM	Ki	Eur J Med Chem (2019) 168: 28-44 [PMID:30798051]
ChEMBL	Competitive type of inhibition of human 5'-nucleotidase using IMP as substrate assessed as inhibitor constant for free enzyme by Lineweaver-Burk plot analysis	B	3.3	pKi	500000	nM	Ki	Eur J Med Chem (2019) 168: 28-44 [PMID:30798051]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.	B	8.23	pKi	5.9	nM	Ki	J Med Chem (1995) 38: 1174-1188 [PMID:7707320]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL	Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand	B	7.55	pKi	28	nM	Ki	J Med Chem (1995) 38: 1174-1188 [PMID:7707320]
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
ChEMBL	Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat adenosine A3 receptor	B	4.98	pKi	10400	nM	Ki	J Med Chem (1995) 38: 1174-1188 [PMID:7707320]
ribonucleotide reductase catalytic subunit M1 in Human [GtoPdb: 2630] [UniProtKB: P23921]
GtoPdb	Inhibition of ADP reduction by ribonucleotide reductase from HeLa cells	-	6	pIC50	1000	nM	IC50	Mol Pharmacol (1982) 21: 474-7 [PMID:7048062]
ribonucleotide reductase regulatory subunit M2 in Human [GtoPdb: 2631] [UniProtKB: P31350]
GtoPdb	Inhibition of ADP reduction by ribonucleotide reductase from HeLa cells	-	6	pIC50	1000	nM	IC50	Mol Pharmacol (1982) 21: 474-7 [PMID:7048062]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]