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ChEMBL ligand: CHEMBL917 (5-Fluoro-2-deoxyuridine, 5-fudr, Floxuridine, Fluoruridine deoxyribose, F.u.d.r., Fudr, FUDR, NSC-27640) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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thymidylate synthetase/Thymidylate synthase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3160] [GtoPdb: 2642] [UniProtKB: P07607] | ||||||||
ChEMBL | Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in permeabilised cells. | B | 4.23 | pIC50 | 59000 | nM | IC50 | J Med Chem (1996) 39: 4569-4575 [PMID:8917645] |
ChEMBL | Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells. | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (1996) 39: 4569-4575 [PMID:8917645] |
ChEMBL | Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells. | B | 5.14 | pIC50 | 7300 | nM | IC50 | J Med Chem (1996) 39: 4569-4575 [PMID:8917645] |
ChEMBL | Thymidylate synthase inhibition in thymidine kinase deficient LM cells after 2 hr treatment | B | 5.27 | pIC50 | 5400 | nM | IC50 | J Med Chem (2001) 44: 4475-4480 [PMID:11728193] |
ChEMBL | Thymidylate synthase inhibition in wild type LM cells after 2 hr treatment | B | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (2001) 44: 4475-4480 [PMID:11728193] |
ChEMBL | Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells. | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (1996) 39: 4569-4575 [PMID:8917645] |
ChEMBL | Thymidylate synthase inhibition in thymidine kinase deficient /TK cells after 2 hr treatment | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2001) 44: 4475-4480 [PMID:11728193] |
ChEMBL | Thymidylate synthase inhibition in L1210 mouse leukemia cells after 2 hr treatment | B | 8.1 | pIC50 | 7.9 | nM | IC50 | J Med Chem (2001) 44: 4475-4480 [PMID:11728193] |
ChEMBL | Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 hrs by liquid scintillation counting | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014] |
ChEMBL | Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24 hrs by liquid scintillation counting | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014] |
ChEMBL | Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 15 mins by liquid scintillation counting | B | 9.22 | pIC50 | 0.6 | nM | IC50 | Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014] |
ChEMBL | Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 15 mins by liquid scintillation counting | B | 9.22 | pIC50 | 0.6 | nM | IC50 | Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014] |
ChEMBL | Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 hrs by liquid scintillation counting | B | 9.4 | pIC50 | 0.4 | nM | IC50 | Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014] |
ChEMBL | Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 hrs by liquid scintillation counting | B | 9.4 | pIC50 | 0.4 | nM | IC50 | Eur J Med Chem (2011) 46: 993-1005 [PMID:21330014] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]