ChEMBL ligand: CHEMBL20943
σ2/Sigma intracellular receptor 2 in Rat [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] There should be some charts here, you may need to enable JavaScript!
Vesicular acetylcholine transporter in Torpedo californica [ChEMBL: CHEMBL3313] [UniProtKB: P81721] Vesicular acetylcholine transporter in Human [ChEMBL: CHEMBL4767] [GtoPdb: 1013] [UniProtKB: Q16572] Vesicular acetylcholine transporter in Rat [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
σ2/Sigma intracellular receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7]
ChEMBL	Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 60 mins by liquid scintillation counting method	B	7.2	pKi	63.4	nM	Ki	J Med Chem (2018) 61: 6937-6943 [PMID:29969030]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
ChEMBL	Displacement of (+)-[3H]pentazocine from sigma1 receptor in rat brain membranes after 60 mins by liquid scintillation counting method	B	7.56	pKi	27.4	nM	Ki	J Med Chem (2018) 61: 6937-6943 [PMID:29969030]
ChEMBL	Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation counting	B	7.66	pKi	22.1	nM	Ki	Bioorg Med Chem (2012) 20: 4936-4941 [PMID:22831799]
Vesicular acetylcholine transporter in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313] [UniProtKB: P81721]
ChEMBL	Displacement of [3H]vesamicol from Vesamicol receptor of Torpedo californica	B	7.47	pIC50	34	nM	IC50	J Med Chem (1991) 34: 2638-2643 [PMID:1875353]
Vesicular acetylcholine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4767] [GtoPdb: 1013] [UniProtKB: Q16572]
GtoPdb	-	-	8.7	pKi	2	nM	Ki	Biochem Pharmacol (1995) 49: 791-7 [PMID:7702637]
ChEMBL	Inhibition of active transport of [3H]acetylcholine using purified Torpedo californica synaptic vesicles	B	5.52	pIC50	3000	nM	IC50	J Med Chem (1989) 32: 1217-1230 [PMID:2724295]
ChEMBL	Inhibition of active transport of [3H]acetylcholine using purified Torpedo californica synaptic vesicles	B	7.4	pIC50	40	nM	IC50	J Med Chem (1989) 32: 1217-1230 [PMID:2724295]
Vesicular acetylcholine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
ChEMBL	Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cell membranes after 60 mins by liquid scintillation counting method	B	7.31	pKi	48.6	nM	Ki	J Med Chem (2018) 61: 6937-6943 [PMID:29969030]
ChEMBL	Displacement of (-)-[3H]vesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 60 mins by liquid scintillation counting in presence of DTG	B	7.47	pKi	33.9	nM	Ki	Bioorg Med Chem (2012) 20: 4936-4941 [PMID:22831799]
ChEMBL	Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting	B	7.48	pKi	32.9	nM	Ki	Bioorg Med Chem (2012) 20: 4936-4941 [PMID:22831799]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]