ChEMBL ligand: CHEMBL20943
σ2/Sigma intracellular receptor 2 in Rat [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] There should be some charts here, you may need to enable JavaScript!
Vesicular acetylcholine transporter in Torpedo californica [ChEMBL: CHEMBL3313] [UniProtKB: P81721] Vesicular acetylcholine transporter in Human [ChEMBL: CHEMBL4767] [GtoPdb: 1013] [UniProtKB: Q16572] Vesicular acetylcholine transporter in Rat [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
σ2/Sigma intracellular receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105864] [GtoPdb: 2553] [UniProtKB: Q5U3Y7]
ChEMBL	Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 60 mins by liquid scintillation counting method	B	7.2	pKi	63.4	nM	Ki	J Med Chem (2018) 61: 6937-6943 [PMID:29969030]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
ChEMBL	Displacement of (+)-[3H]pentazocine from sigma1 receptor in rat brain membranes after 60 mins by liquid scintillation counting method	B	7.56	pKi	27.4	nM	Ki	J Med Chem (2018) 61: 6937-6943 [PMID:29969030]
ChEMBL	Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation counting	B	7.66	pKi	22.1	nM	Ki	Bioorg Med Chem (2012) 20: 4936-4941 [PMID:22831799]
Vesicular acetylcholine transporter in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313] [UniProtKB: P81721]
ChEMBL	Displacement of [3H]vesamicol from Vesamicol receptor of Torpedo californica	B	7.47	pIC50	34	nM	IC50	J Med Chem (1991) 34: 2638-2643 [PMID:1875353]
Vesicular acetylcholine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4767] [GtoPdb: 1013] [UniProtKB: Q16572]
GtoPdb	-	-	8.7	pKi	2	nM	Ki	Biochem Pharmacol (1995) 49: 791-7 [PMID:7702637]
ChEMBL	Inhibition of active transport of [3H]acetylcholine using purified Torpedo californica synaptic vesicles	B	5.52	pIC50	3000	nM	IC50	J Med Chem (1989) 32: 1217-1230 [PMID:2724295]
ChEMBL	Inhibition of active transport of [3H]acetylcholine using purified Torpedo californica synaptic vesicles	B	7.4	pIC50	40	nM	IC50	J Med Chem (1989) 32: 1217-1230 [PMID:2724295]
Vesicular acetylcholine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2125] [GtoPdb: 1013] [UniProtKB: Q62666]
ChEMBL	Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cell membranes after 60 mins by liquid scintillation counting method	B	7.31	pKi	48.6	nM	Ki	J Med Chem (2018) 61: 6937-6943 [PMID:29969030]
ChEMBL	Displacement of (-)-[3H]vesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 60 mins by liquid scintillation counting in presence of DTG	B	7.47	pKi	33.9	nM	Ki	Bioorg Med Chem (2012) 20: 4936-4941 [PMID:22831799]
ChEMBL	Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting	B	7.48	pKi	32.9	nM	Ki	Bioorg Med Chem (2012) 20: 4936-4941 [PMID:22831799]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]