ChEMBL ligand: CHEMBL494753 (Estrone Sulphate)
ABCC1/Multidrug resistance-associated protein 1 in Human [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527] There should be some charts here, you may need to enable JavaScript!
ABCC4/Multidrug resistance-associated protein 4 in Human [ChEMBL: CHEMBL1743128] [GtoPdb: 782] [UniProtKB: O15439] There should be some charts here, you may need to enable JavaScript!
OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 3/Solute carrier family 22 member 8 in Rat [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] There should be some charts here, you may need to enable JavaScript!
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6] There should be some charts here, you may need to enable JavaScript!
OATP1C1/Solute carrier organic anion transporter family member 1C1 in Mouse [ChEMBL: CHEMBL2073688] [GtoPdb: 1222] [UniProtKB: Q9ERB5] There should be some charts here, you may need to enable JavaScript!
Steryl-sulfatase in Human [ChEMBL: CHEMBL3559] [UniProtKB: P08842] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
ChEMBL	TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicle from MRP1-expressing HeLa cells	F	6.35	pKi	450	nM	Ki	J Biol Chem (2001) 276: 6404-6411 [PMID:11102445]
ABCC4/Multidrug resistance-associated protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743128] [GtoPdb: 782] [UniProtKB: O15439]
ChEMBL	TP_TRANSPORTER: inhibition of DHEAS in membrane vesicles from MRP4-expressing Sf9 cells	F	4.02	pIC50	95000	nM	IC50	Biochem J (2003) 371: 361-367 [PMID:12523936]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing Sf9 cells	F	4.35	pIC50	45000	nM	IC50	Biochem J (2003) 371: 361-367 [PMID:12523936]
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	4.24	pKi	58000	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	4.24	pKi	57543.99	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
Organic anion transporter 3/Solute carrier family 22 member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7]
ChEMBL	TP_TRANSPORTER: inhibition of PCG uptake in OAT3-expressing LLC-PK1 cells	F	5.04	pKi	9100	nM	Ki	Mol Pharmacol (2002) 61: 982-988 [PMID:11961115]
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing HeLa cells	F	5.89	pKi	1300	nM	Ki	Am J Physiol (1996) 270: F326-F331 [PMID:8779894]
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in OATP-C-expressing HEK293 cells	F	7.34	pKi	45.8	nM	Ki	Pharm Res (2001) 18: 1262-1269 [PMID:11683238]
GtoPdb	Measured using estropipate, which is estrone-3-sulfate stabilized with piperazine.	-	7.22	pIC50	60	nM	IC50	Curr Chem Genomics (2010) 4: 1-8 [PMID:20448812]
OATP1C1/Solute carrier organic anion transporter family member 1C1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073688] [GtoPdb: 1222] [UniProtKB: Q9ERB5]
ChEMBL	TP_TRANSPORTER: inhibition of L-T4 uptake in Oatp14-expressing HEK293 cells	F	4.27	pKi	53100	nM	Ki	Endocrinology (2004) 145: 4384-4391 [PMID:15166123]
Steryl-sulfatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559] [UniProtKB: P08842]
ChEMBL	Inhibitory activity against steroid sulfatase (STS) desulfation of 4-MUS	B	4.22	pKi	60000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 151-155 [PMID:14684318]
ChEMBL	Inhibition of steroid sulfatase activity of JEG-3 cells	B	5.12	pIC50	7600	nM	IC50	J Med Chem (2000) 43: 4465-4478 [PMID:11087571]
ChEMBL	Estrone sulfatase activity against homogenized human JEG-3 cells was determined by measuring the [3H]E1 obtained from [3H]E1S	B	5.12	pIC50	7600	nM	IC50	Bioorg Med Chem Lett (1998) 8: 1891-1896 [PMID:9873454]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]