microcystin-LR [Ligand Id: 4735] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL444092 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Protein phosphatase 2C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2437] [UniProtKB: P35813] | ||||||||
| ChEMBL | Inhibitory concentration required against protein phosphatase 1 using pNPP assay | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2903-2906 [PMID:14611854] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Observed inhibition activity of the compounds against protein phosphatases 1 (PP1) | B | 8.93 | pIC50 | 1.17 | nM | IC50 | J Med Chem (1997) 40: 3199-3206 [PMID:9379439] |
| ChEMBL | Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscle | B | 10 | pIC50 | 0.1 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1029-1034 |
| Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4284] [UniProtKB: P63151] | ||||||||
| ChEMBL | Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A) | B | 10.19 | pIC50 | 0.07 | nM | IC50 | J Med Chem (1997) 40: 3199-3206 [PMID:9379439] |
| Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4763] [UniProtKB: Q15172] | ||||||||
| ChEMBL | Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytes | B | 10 | pIC50 | 0.1 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1029-1034 |
| Serine-threonine protein phosphatase 2A regulatory subunit in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3] | ||||||||
| ChEMBL | Inhibitory concentration required against protein phosphatase 2A using pNPP assay | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2903-2906 [PMID:14611854] |
| ChEMBL | Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A) | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4438] [UniProtKB: P36873] | ||||||||
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in N124D | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in H248N | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in R96A | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 9PP1) mutants by natural toxins in R221S | B | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D208A | B | 8.72 | pIC50 | 1.9 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in Y272F | B | 9.1 | pIC50 | 0.8 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in C127S | B | 9.25 | pIC50 | 0.56 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild type | B | 10.7 | pIC50 | 0.02 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D220V | B | 10.7 | pIC50 | 0.02 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in E275R | B | 11 | pIC50 | 0.01 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| protein phosphatase 2 catalytic subunit alpha in Human [GtoPdb: 3263] [UniProtKB: P67775] | ||||||||
| GtoPdb | - | - | 10 | pIC50 | 0.1 | nM | IC50 | Br J Pharmacol (2022) 179: 65-83 [PMID:34519023] |
| protein phosphatase 1 catalytic subunit alpha in Human [GtoPdb: 3264] [UniProtKB: P62136] | ||||||||
| GtoPdb | - | - | 10 | pIC50 | 0.1 | nM | IC50 | Bioorg Med Chem (1997) 5: 1739-50 [PMID:9354230] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
