microcystin-LR [Ligand Id: 4735] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL444092
  • Protein phosphatase 2C alpha in Human [ChEMBL: CHEMBL2437] [UniProtKB: P35813]
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  • protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
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  • Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform in Human [ChEMBL: CHEMBL4284] [UniProtKB: P63151]
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  • Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human [ChEMBL: CHEMBL4763] [UniProtKB: Q15172]
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  • Serine-threonine protein phosphatase 2A regulatory subunit in Chicken [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3]
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  • Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human [ChEMBL: CHEMBL4438] [UniProtKB: P36873]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Protein phosphatase 2C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2437] [UniProtKB: P35813]
ChEMBL Inhibitory concentration required against protein phosphatase 1 using pNPP assay B 8.52 pIC50 3 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2903-2906 [PMID:14611854]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL Observed inhibition activity of the compounds against protein phosphatases 1 (PP1) B 8.93 pIC50 1.17 nM IC50 J. Med. Chem. (1997) 40: 3199-3206 [PMID:9379439]
ChEMBL Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscle B 10 pIC50 0.1 nM IC50 Bioorg. Med. Chem. Lett. (1993) 3: 1029-1034
Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4284] [UniProtKB: P63151]
ChEMBL Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A) B 10.19 pIC50 0.07 nM IC50 J. Med. Chem. (1997) 40: 3199-3206 [PMID:9379439]
Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4763] [UniProtKB: Q15172]
ChEMBL Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytes B 10 pIC50 0.1 nM IC50 Bioorg. Med. Chem. Lett. (1993) 3: 1029-1034
Serine-threonine protein phosphatase 2A regulatory subunit in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3]
ChEMBL Inhibitory concentration required against protein phosphatase 2A using pNPP assay B 8.52 pIC50 3 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2903-2906 [PMID:14611854]
ChEMBL Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A) B 10 pIC50 0.1 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4438] [UniProtKB: P36873]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in N124D B 6.7 pIC50 200 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in H248N B 7.46 pIC50 35 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in R96A B 7.46 pIC50 35 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 9PP1) mutants by natural toxins in R221S B 7.54 pIC50 29 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D208A B 8.72 pIC50 1.9 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in Y272F B 9.1 pIC50 0.8 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in C127S B 9.25 pIC50 0.56 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild type B 10.7 pIC50 0.02 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D220V B 10.7 pIC50 0.02 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in E275R B 11 pIC50 0.01 nM IC50 J. Med. Chem. (2002) 45: 1151-1175 [PMID:11881984]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]