MRS1476 [Ligand Id: 471] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL321845 (MRS-1476) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Displacement of specific [3H]-CGS- 21680R-PIA binding to Adenosine A1 receptor in rat brain membranes. | B | 7.39 | pKi | 41 | nM | Ki | J Med Chem (1999) 42: 706-721 [PMID:10052977] |
| A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
| ChEMBL | Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal membranes. | B | 5.21 | pKi | 6130 | nM | Ki | J Med Chem (1999) 42: 706-721 [PMID:10052977] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Displacement of specific [125 I]AB-MECA binding at human Adenosine A3 receptor expressed in HEK cells | B | 7.67 | pKi | 7.67 | uM | Log Ki | J Med Chem (1999) 42: 706-721 [PMID:10052977] |
| ChEMBL | Displacement of specific [125 I]AB-MECA binding at human Adenosine A3 receptor expressed in HEK cells | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (1999) 42: 706-721 [PMID:10052977] |
| GtoPdb | - | - | 7.7 | pKi | - | - | - | J Med Chem (1998) 41: 3186-201 [PMID:9703464] |
| ChEMBL | Displacement of [3H]MRE 3008F20 from human adenosine A3 receptor expressed in CHO cells | B | 7.87 | pKi | 13.4 | nM | Ki | J Med Chem (2006) 49: 4085-4097 [PMID:16821770] |
| A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
| ChEMBL | Displacement of specific [125I]AB-MECA binding at rat Adenosine A3 receptor stably expressed in CHO cells | B | 6.39 | pKi | 410 | nM | Ki | J Med Chem (1999) 42: 706-721 [PMID:10052977] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
