MRS1186 [Ligand Id: 469] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL329722 |
|---|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine receptor A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Displacement of [3H]-(R)-PIA from Adenosine A1 receptor of rat cerebral cortex membranes | B | 6.55 | pKi | 283 | nM | Ki | J Med Chem (1996) 39: 4142-4148 [PMID:8863790] |
| A2A receptor/Adenosine receptor A2a in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
| ChEMBL | Displacement of [3H]-CGH 21680 from Adenosine A2A receptor of rat striatal membranes | B | 6.97 | pKi | 106 | nM | Ki | J Med Chem (1996) 39: 4142-4148 [PMID:8863790] |
| A3 receptor/Adenosine receptor A3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| GtoPdb | - | - | 8.1 | pKi | - | - | - | J Med Chem (1996) 39: 4142-8 [PMID:8863790] |
| ChEMBL | Displacement of [3H]MRE 3008F20 from human adenosine A3 receptor expressed in CHO cells | B | 8.11 | pKi | 7.7 | nM | Ki | J Med Chem (2006) 49: 4085-4097 [PMID:16821770] |
| ChEMBL | In vitro binding affinity at human Adenosine A3 receptor from HEK293 cells by [125I]AB-MECA displacement. | B | 8.12 | pKi | 7.66 | nM | Ki | J Med Chem (1996) 39: 4142-4148 [PMID:8863790] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
