ChEMBL ligand: CHEMBL315984
A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Displacement of specific [3H](R)-PIA binding at adenosine A1 receptor from rat brain membranes.	B	5.23	pKi	5930	nM	Ki	J Med Chem (1997) 40: 2596-2608 [PMID:9258367]
ChEMBL	Binding affinity against adenosine A1 receptor in rat cerebral cortex membrane by radioligand binding assay using [3H](R)-PIA.	B	5.23	pKi	5930	nM	Ki	J Med Chem (1996) 39: 4667-4675 [PMID:8917655]
ChEMBL	Displacement of [3H]-R-PIA from adenosine A1 receptor of rat brain membrane	B	5.23	pKi	5930	nM	Ki	J Med Chem (1999) 42: 3055-3065 [PMID:10447949]
ChEMBL	Displacement of [3H](R)-PIA binding to Adenosine A1 receptor in rat brain membranes	B	5.23	pKi	5930	nM	Ki	J Med Chem (1996) 39: 2980-2989 [PMID:8709132]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL	Displacement of specific [3H]-CGS- 21680 binding at Adenosine A2A receptor in rat striatal membranes.	B	5.32	pKi	4770	nM	Ki	J Med Chem (1997) 40: 2596-2608 [PMID:9258367]
ChEMBL	Displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatal membrane	B	5.32	pKi	4770	nM	Ki	J Med Chem (1996) 39: 4667-4675 [PMID:8917655]
ChEMBL	Displacement of [3H]CGS-21680 from Adenosine A2A receptor of rat striatal membrane at 10e-4 uM	B	5.32	pKi	4770	nM	Ki	J Med Chem (1999) 42: 3055-3065 [PMID:10447949]
ChEMBL	Displacement of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal membranes	B	5.32	pKi	4770	nM	Ki	J Med Chem (1996) 39: 2980-2989 [PMID:8709132]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL	Displacement of [125 I]AB-MECA from Adenosine A3 receptor expressed in HEK cells	B	6.96	pKi	110	nM	Ki	J Med Chem (1999) 42: 3055-3065 [PMID:10447949]
ChEMBL	Displacement of specific [125I]AB-MECA binding at human adenosine A3 receptor.	B	6.97	pKi	108	nM	Ki	J Med Chem (1997) 40: 2596-2608 [PMID:9258367]
ChEMBL	Inhibition of [125I]- AB-MECA binding to human Adenosine A3 receptors expressed in HEK cells	B	6.97	pKi	108	nM	Ki	J Med Chem (1996) 39: 4667-4675 [PMID:8917655]
ChEMBL	Displacement of [125]AB-MECA binding to human Adenosine A3 receptor expressed in HEK cells	B	6.97	pKi	108	nM	Ki	J Med Chem (1996) 39: 2980-2989 [PMID:8709132]
GtoPdb	-	-	7	pKi	-	-	-	Neuropharmacology (1997) 36: 1157-65 [PMID:9364471]; J Med Chem (1996) 39: 2980-9 [PMID:8709132]
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
ChEMBL	Binding affinity against rat Adenosine A3 receptor from CHO cells	B	5.38	pKi	4160	nM	Ki	J Med Chem (1996) 39: 2980-2989 [PMID:8709132]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]