ChEMBL ligand: CHEMBL307429 (1,5-dideoxy-1,5-imino-, 1,5-dideoxy-1,5-imino-d-glucitol, 1 deoxynojirimycin, 1-deoxynojirimycin, Bay-h-5595, D-1-deoxynojirimycin, Deoxynojirimycin, Duvoglustat, Moranolin, Moranoline, Nojirimycin, 1-deoxy-)
alpha glucosidase in Human [GtoPdb: 2611] [UniProtKB: P10253] alpha glucosidase/Acidic alpha-glucosidase in Rat [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9] There should be some charts here, you may need to enable JavaScript!
Alpha-galactosidase in Coffea arabica [ChEMBL: CHEMBL5217] [UniProtKB: Q42656] There should be some charts here, you may need to enable JavaScript!
Alpha-galactosidase A in Human [ChEMBL: CHEMBL2524] [UniProtKB: P06280] There should be some charts here, you may need to enable JavaScript!
Alpha-glucosidase in Geobacillus stearothermophilus [ChEMBL: CHEMBL4412] [UniProtKB: P94451] Alpha-glucosidase in Bovine [ChEMBL: CHEMBL2974] [UniProtKB: Q9MYM4] Alpha-glucosidase in Oryza sativa Japonica Group [ChEMBL: CHEMBL5280] [UniProtKB: Q9LGC6] There should be some charts here, you may need to enable JavaScript!
Alpha-L-fucosidase I in Human [ChEMBL: CHEMBL4176] [UniProtKB: P04066] There should be some charts here, you may need to enable JavaScript!
Alpha-mannosidase 2C1 in Rat [ChEMBL: CHEMBL2852] [UniProtKB: P21139] There should be some charts here, you may need to enable JavaScript!
Beta-galactosidase in Rat [ChEMBL: CHEMBL2680] [UniProtKB: D3ZUM4] There should be some charts here, you may need to enable JavaScript!
glucosylceramidase beta/Beta-glucocerebrosidase in Human [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062] There should be some charts here, you may need to enable JavaScript!
Beta-glucosidase in Agrobacterium tumefaciens [ChEMBL: CHEMBL4663] [UniProtKB: P27034] Beta-glucosidase in Human [ChEMBL: CHEMBL3761] [UniProtKB: Q9HCG7] Beta-glucosidase in Prunus avium [ChEMBL: CHEMBL4192] [UniProtKB: Q43014] There should be some charts here, you may need to enable JavaScript!
Beta-glucosidase A in Caldicellulosiruptor saccharolyticus [ChEMBL: CHEMBL4622] [UniProtKB: P10482] There should be some charts here, you may need to enable JavaScript!
Beta-glucosidase cytosolic in Human [ChEMBL: CHEMBL3865] [UniProtKB: Q9H227] There should be some charts here, you may need to enable JavaScript!
UDP-glucose ceramide glucosyltransferase/Ceramide glucosyltransferase in Human [ChEMBL: CHEMBL2063] [GtoPdb: 2528] [UniProtKB: Q16739] There should be some charts here, you may need to enable JavaScript!
Cholinesterase in Equus caballus [ChEMBL: CHEMBL5763] [UniProtKB: P81908] There should be some charts here, you may need to enable JavaScript!
Glycogen debranching enzyme in Human [ChEMBL: CHEMBL5272] [UniProtKB: P35573] Glycogen debranching enzyme in Rabbit [ChEMBL: CHEMBL5273] [UniProtKB: P35574] There should be some charts here, you may need to enable JavaScript!
Lactase-glycosylceramidase in Rat [ChEMBL: CHEMBL3389] [UniProtKB: Q02401] There should be some charts here, you may need to enable JavaScript!
Lactase-phlorizin hydrolase in Human [ChEMBL: CHEMBL1075131] [UniProtKB: P09848] There should be some charts here, you may need to enable JavaScript!
Liver X receptor-α/LXR-alpha in Human [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133] There should be some charts here, you may need to enable JavaScript!
Liver X receptor-β/LXR-beta in Human [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055] There should be some charts here, you may need to enable JavaScript!
alpha glucosidase/Lysosomal alpha-glucosidase in Human [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253] alpha glucosidase/Lysosomal alpha-glucosidase in Mouse [ChEMBL: CHEMBL1667668] [GtoPdb: 2611] [UniProtKB: P70699] There should be some charts here, you may need to enable JavaScript!
maltase-glucoamylase/Maltase-glucoamylase in Human [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451] There should be some charts here, you may need to enable JavaScript!
Mannosidase 2 alpha 1 in Rat [ChEMBL: CHEMBL2257] [UniProtKB: P28494] There should be some charts here, you may need to enable JavaScript!
Neutral alpha-glucosidase AB in Human [ChEMBL: CHEMBL2519] [UniProtKB: Q14697] There should be some charts here, you may need to enable JavaScript!
Neutral alpha-glucosidase C in Mouse [ChEMBL: CHEMBL3635] [UniProtKB: Q8BVW0] There should be some charts here, you may need to enable JavaScript!
Sucrase-isomaltase in Human [ChEMBL: CHEMBL2748] [UniProtKB: P14410] Sucrase-isomaltase in Rat [ChEMBL: CHEMBL3114] [UniProtKB: P23739] There should be some charts here, you may need to enable JavaScript!
Trehalase in Human [ChEMBL: CHEMBL3087] [UniProtKB: O43280] Trehalase in Rat [ChEMBL: CHEMBL3248] [UniProtKB: O70282] There should be some charts here, you may need to enable JavaScript!
Uncharacterized protein in Pig [ChEMBL: CHEMBL2176863] [UniProtKB: I3LIR5] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
alpha glucosidase in Human [GtoPdb: 2611] [UniProtKB: P10253]
GtoPdb	-	-	6.82	pKi	150	nM	Ki	Bioorg Med Chem Lett (1997) 7: 355-360
alpha glucosidase/Acidic alpha-glucosidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9]
ChEMBL	Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver	B	4.6	pIC50	25000	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL	Inhibition of rat liver lysosome alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test	B	6.4	pIC50	400	nM	IC50	J Nat Prod (2002) 65: 1875-1881 [PMID:12502331]
ChEMBL	Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver	B	6.4	pIC50	400	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL	Inhibition of rat intestinal maltase assessed as D-glucose release after 30 mins by Glucose B-test	B	6.44	pIC50	360	nM	IC50	J Nat Prod (2002) 65: 1875-1881 [PMID:12502331]
ChEMBL	Concentration that causes 50% inhibition of mammalian alpha-glucosidase (maltase) was determined in rat intestine	B	6.44	pIC50	360	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL	Inhibition of rat intestinal maltase using moltose as substrate	B	6.44	pIC50	360	nM	IC50	J Med Chem (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL	Inhibition of rat intestinal brush border membrane maltase	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
Alpha-galactosidase in Coffea arabica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5217] [UniProtKB: Q42656]
ChEMBL	Inhibition of alpha-galactosidase in green coffee bean after 30 mins by spectrophotometric analysis	B	4.64	pIC50	23000	nM	IC50	Medchemcomm (2013) 4: 387-393
Alpha-galactosidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2524] [UniProtKB: P06280]
ChEMBL	Compound tested for inhibition of alpha-galactosidase from Aspergillus niger	B	4.74	pKi	18000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 73-75 [PMID:14684301]
Alpha-glucosidase in Geobacillus stearothermophilus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4412] [UniProtKB: P94451]
ChEMBL	Inhibition of alpha glucosidase from bacillus stearothermophilus	B	5.78	pIC50	1670	nM	IC50	Bioorg Med Chem Lett (2008) 18: 954-958 [PMID:18166456]
Alpha-glucosidase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2974] [UniProtKB: Q9MYM4]
ChEMBL	Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver	B	4.68	pIC50	21000	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL	Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver	B	6.4	pIC50	400	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
Alpha-glucosidase in Oryza sativa Japonica Group (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5280] [UniProtKB: Q9LGC6]
ChEMBL	Inhibitory activity against alpha-Glucosidase from rice	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715]
ChEMBL	Inhibitory concentration against rice alpha-glucosidase	B	7.52	pIC50	30	nM	IC50	J Med Chem (2005) 48: 2036-2044 [PMID:15771446]
Alpha-L-fucosidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4176] [UniProtKB: P04066]
ChEMBL	Concentration that causes 50% inhibition of mammalian alpha-L-fucosidase was determined in bovine epididymis	B	4.59	pIC50	26000	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
Alpha-mannosidase 2C1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2852] [UniProtKB: P21139]
ChEMBL	Inhibition of soluble Alpha-mannosidase II in rat liver	B	4.3	pIC50	<50000	nM	IC50	J Med Chem (1995) 38: 2349-2356 [PMID:7608901]
Beta-galactosidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2680] [UniProtKB: D3ZUM4]
ChEMBL	Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestine	B	4.52	pIC50	30000	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL	Concentration that causes 50% inhibition of mammalian beta-galactosidase (lactase ) was determined in rat intestine	B	4.57	pIC50	27000	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
glucosylceramidase beta/Beta-glucocerebrosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062]
ChEMBL	Inhibition of human lysosomal beta-glucocerebrosidase	B	4.1	pKi	79000	nM	Ki	Bioorg Med Chem Lett (2014) 24: 2777-2780 [PMID:24803362]
ChEMBL	Inhibitory activity against beta-glucosidase of sweet almond	B	4.33	pKi	47000	nM	Ki	Bioorg Med Chem Lett (1999) 9: 615-618 [PMID:10098675]
ChEMBL	Competitive Inhibition constant on Asp. Wentii beta Glucosidase at pH 5.0	B	5.7	pKi	2000	nM	Ki	Bioorg Med Chem Lett (1992) 2: 27-32
Beta-glucosidase in Agrobacterium tumefaciens (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4663] [UniProtKB: P27034]
ChEMBL	Inhibition of Agrobacterium sp. beta-glucosidase	B	4.92	pKi	12000	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2067-2070 [PMID:16481162]
ChEMBL	Inhibition of Agrobacterium sp. beta glucosidase	B	4.92	pKi	12000	nM	Ki	Bioorg Med Chem Lett (2014) 24: 2777-2780 [PMID:24803362]
Beta-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3761] [UniProtKB: Q9HCG7]
ChEMBL	Inhibition of non-lysosomal glucosylceramidase	B	4.52	pIC50	30000	nM	IC50	Eur J Med Chem (2011) 46: 1949-1963 [PMID:21354674]
ChEMBL	Displacement of 4-methylumbelliferyl from non-lysosomal GBA2 by fluorimetry	B	4.54	pIC50	28800	nM	IC50	Bioorg Med Chem (2010) 18: 267-273 [PMID:19931460]
ChEMBL	Inhibition of GBA2 by HPLC	B	4.68	pIC50	21000	nM	IC50	J Med Chem (2010) 53: 689-698 [PMID:20000679]
ChEMBL	Inhibition of human GBA2	B	4.7	pIC50	20000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6600-6603 [PMID:19853441]
Beta-glucosidase in Prunus avium (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4192] [UniProtKB: Q43014]
ChEMBL	Inhibitory activity against sweet almond Beta-glucosidase	B	5.02	pKi	9500	nM	Ki	Bioorg Med Chem Lett (1991) 1: 667-672
ChEMBL	Inhibitory activity against beta-Glucosidase from sweet almond	B	4.09	pIC50	81000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715]
Beta-glucosidase A in Caldicellulosiruptor saccharolyticus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4622] [UniProtKB: P10482]
ChEMBL	Inhibition of Caldocellum saccharolyticum beta-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test	B	4	pIC50	100000	nM	IC50	J Nat Prod (2002) 65: 1875-1881 [PMID:12502331]
ChEMBL	Inhibitory activity against beta-Glucosidase from Caldocellum saccharolyticum	B	4.26	pIC50	55000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715]
Beta-glucosidase cytosolic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3865] [UniProtKB: Q9H227]
ChEMBL	Inhibitory concentration against beta-glucosidase	B	4.1	pIC50	80000	nM	IC50	J Med Chem (2005) 48: 2036-2044 [PMID:15771446]
UDP-glucose ceramide glucosyltransferase/Ceramide glucosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2063] [GtoPdb: 2528] [UniProtKB: Q16739]
ChEMBL	Inhibition of GCS by cell-based assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2010) 53: 689-698 [PMID:20000679]
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL	Inhibition of equine serum BuChE using p-nitrophenyl glycopyranoside as substrate by DTNB-reagent based Ellman's method	B	5	pIC50	10000	nM	IC50	RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560]
Glycogen debranching enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5272] [UniProtKB: P35573]
ChEMBL	Inhibition of glycogen glycogen de-branching enzyme by HPLC	B	5	pIC50	10000	nM	IC50	J Med Chem (2010) 53: 689-698 [PMID:20000679]
Glycogen debranching enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5273] [UniProtKB: P35574]
ChEMBL	Inhibition of rabbit muscle amylo-1,6-glucosidase	B	6.72	pIC50	190	nM	IC50	Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
Lactase-glycosylceramidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3389] [UniProtKB: Q02401]
ChEMBL	Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometry	B	4.31	pIC50	49000	nM	IC50	Bioorg Med Chem (2011) 19: 3558-3568 [PMID:21546253]
ChEMBL	Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method	B	4.47	pIC50	34000	nM	IC50	J Med Chem (1995) 38: 2349-2356 [PMID:7608901]
ChEMBL	Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestine	B	4.59	pIC50	26000	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL	Inhibition of rat intestinal lactase using lactose as substrate	B	4.59	pIC50	26000	nM	IC50	J Med Chem (2012) 55: 10347-10362 [PMID:23106358]
Lactase-phlorizin hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075131] [UniProtKB: P09848]
ChEMBL	Inhibition of lactase by HPLC	B	4.21	pIC50	62000	nM	IC50	J Med Chem (2010) 53: 689-698 [PMID:20000679]
Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
ChEMBL	Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay	F	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2008) 16: 4272-4285 [PMID:18343126]
Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055]
ChEMBL	Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay	F	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2008) 16: 4272-4285 [PMID:18343126]
alpha glucosidase/Lysosomal alpha-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253]
ChEMBL	Inhibitory activity against alpha-glucosidase of yeast	B	4.6	pKi	25000	nM	Ki	Bioorg Med Chem Lett (1999) 9: 615-618 [PMID:10098675]
GtoPdb	-	-	6.82	pKi	150	nM	Ki	Bioorg Med Chem Lett (1997) 7: 355-360
ChEMBL	Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase	B	6.82	pKi	150	nM	Ki	Bioorg Med Chem Lett (1997) 7: 355-360
ChEMBL	Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and measured after 30 min by fluorescence spectrophotometer analysis	B	7.23	pKi	59	nM	Ki	J Med Chem (2022) 65: 2329-2341 [PMID:35072486]
ChEMBL	Binding affinity to human lysosomal acid alpha-glucosidase assessed as inhibition constant incubated for 30 mins by fluorescence based spectrophotometry	B	7.23	pKi	59	nM	Ki	J Med Chem (2023) 66: 9023-9039 [PMID:37314161]
ChEMBL	Inhibitory activity was determined against baker's yeast Alpha-Glucosidase	B	4.04	pIC50	91900	nM	IC50	Bioorg Med Chem Lett (1994) 4: 2643-2648
ChEMBL	Inhibition of human lysosomal alpha glucosidase	B	5.82	pIC50	1500	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6600-6603 [PMID:19853441]
ChEMBL	Inhibition of lysosomal alpha-glucosidase by HPLC	B	5.82	pIC50	1500	nM	IC50	J Med Chem (2010) 53: 689-698 [PMID:20000679]
ChEMBL	Inhibition of human lysosomal alpha-glucosidase	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
ChEMBL	Inhibition of maltase in human Caco-2 cell model system after 2 hrs	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
alpha glucosidase/Lysosomal alpha-glucosidase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667668] [GtoPdb: 2611] [UniProtKB: P70699]
ChEMBL	Enzyme Activity Assay: Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-phosphate buffer (30 mM sodium citrate, 40 mM sodium phosphate dibasic, pH 4.0), and 2.5% DMSO to rows 1-12. Following incubation at 37° C. with 5% CO2 for about 3 h, 70 μL of stop buffer (0.4 M glycine pH 10.8) was added to rows 1-12. The plate was read in a Victor2 multilabel counter-Wallac fluorescent plate reader and the fluorescence at F460 nm was determined b at an excitation of 355 nm and emission of 460 nm using 1 second read time per well. Enzyme activity per μg of protein in the supernatant was calculated from the amount of fluorescence emitted, which is directly proportional to the amount of substrate hydrolyzed, and hence, the amount of Gaa activity in the lysate.	B	4.01	pEC50	98800	nM	EC50	US-9181184-B2. Method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives (2015)
maltase-glucoamylase/Maltase-glucoamylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451]
ChEMBL	Inhibition of alpha-glucosidase (unknown origin) preincubated for 5 mins followed by addition of pNPG substrate and measured after 30 mins by spectrophotometric method	B	5.1	pIC50	8030	nM	IC50	J Nat Prod (2021) 84: 1534-1543 [PMID:33979163]
ChEMBL	Inhibition of maltase by HPLC	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2010) 53: 689-698 [PMID:20000679]
ChEMBL	Inhibition of human alpha-glucosidase	B	5.85	pIC50	1400	nM	IC50	Eur J Med Chem (2021) 224: 113716-113716 [PMID:34340042]
ChEMBL	Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method	B	6.44	pIC50	360	nM	IC50	J Med Chem (1995) 38: 2349-2356 [PMID:7608901]
ChEMBL	Inhibitory concentration against human alpha-glucosidase	B	7.4	pIC50	40	nM	IC50	J Med Chem (2005) 48: 2036-2044 [PMID:15771446]
Mannosidase 2 alpha 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2257] [UniProtKB: P28494]
ChEMBL	Competitive Inhibitory activity against Golgi Alpha-mannosidase II	B	4.3	pKi	<50000	nM	Ki	J Med Chem (1995) 38: 2349-2356 [PMID:7608901]
ChEMBL	Inhibition of golgi Alpha-mannosidase II in rat liver	B	4.3	pIC50	<50000	nM	IC50	J Med Chem (1995) 38: 2349-2356 [PMID:7608901]
Neutral alpha-glucosidase AB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2519] [UniProtKB: Q14697]
ChEMBL	Competitive Inhibition constant on yeast alpha Glucosidase at pH 6.0	B	4.64	pKi	23000	nM	Ki	Bioorg Med Chem Lett (1992) 2: 27-32
ChEMBL	Competitive Inhibition constant on yeast alpha Glucosidase at pH 7.0	B	4.68	pKi	21000	nM	Ki	Bioorg Med Chem Lett (1992) 2: 27-32
ChEMBL	Competitive Inhibition constant on rice alpha Glucosidase at pH 5.0	B	6.8	pKi	160	nM	Ki	Bioorg Med Chem Lett (1992) 2: 27-32
ChEMBL	Competitive Inhibition constant on rice alpha Glucosidase at pH 6.0	B	7.85	pKi	14	nM	Ki	Bioorg Med Chem Lett (1992) 2: 27-32
ChEMBL	Concentration that causes 50% inhibition of mammalian alpha-mannosidase (Golgi I) was determined in rat liver	B	4.6	pIC50	25000	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL	Tested for competitive inhibition of endoplasmic reticulum alpha-glucosidase II.	B	5.89	pIC50	1300	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
Neutral alpha-glucosidase C in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3635] [UniProtKB: Q8BVW0]
ChEMBL	Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestine	B	4.47	pIC50	34000	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL	Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestine	B	6.52	pIC50	300	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
Sucrase-isomaltase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2748] [UniProtKB: P14410]
ChEMBL	Inhibition of sucrase by HPLC	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2010) 53: 689-698 [PMID:20000679]
Sucrase-isomaltase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3114] [UniProtKB: P23739]
ChEMBL	Tested in vitro for the inhibition constant against rat small intestinal sucrase	B	7.62	pKi	24	nM	Ki	Bioorg Med Chem Lett (1997) 7: 355-360
ChEMBL	Inhibition of rat intestinal isomaltase assessed as production of p-nitrophenol at by spectrophotometry	B	6.19	pIC50	650	nM	IC50	Bioorg Med Chem (2011) 19: 3558-3568 [PMID:21546253]
ChEMBL	Inhibitory concentration against rat intestinal maltase	B	6.19	pIC50	650	nM	IC50	J Med Chem (2005) 48: 2036-2044 [PMID:15771446]
ChEMBL	Inhibition of rat intestinal isomaltase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay	B	6.21	pIC50	610	nM	IC50	Eur J Med Chem (2021) 224: 113716-113716 [PMID:34340042]
ChEMBL	Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometry	B	6.29	pIC50	510	nM	IC50	Bioorg Med Chem (2011) 19: 3558-3568 [PMID:21546253]
ChEMBL	Inhibitory activity against rat intestinal maltase using disaccharide	B	6.44	pIC50	360	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715]
ChEMBL	Inhibition of rat intestinal isomaltase using isomaltase as substrate	B	6.52	pIC50	300	nM	IC50	J Med Chem (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL	Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method	B	6.52	pIC50	300	nM	IC50	J Med Chem (1995) 38: 2349-2356 [PMID:7608901]
ChEMBL	Inhibitory activity against rat intestinal isomaltase using disaccharide	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715]
ChEMBL	Inhibition of rat intestinal brush border membrane sucrase	B	6.68	pIC50	210	nM	IC50	Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
ChEMBL	Inhibitory activity against rat intestinal sucrase using disaccharide	B	6.68	pIC50	210	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715]
ChEMBL	Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method	B	6.68	pIC50	210	nM	IC50	J Med Chem (1995) 38: 2349-2356 [PMID:7608901]
ChEMBL	Inhibition of rat intestinal sucrase using sucrose as substrate	B	6.68	pIC50	210	nM	IC50	J Med Chem (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL	Inhibition of rat intestinal sucrase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay	B	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2021) 224: 113716-113716 [PMID:34340042]
ChEMBL	Inhibition of rat intestinal brush border membrane isomaltase	B	6.8	pIC50	160	nM	IC50	Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718]
Trehalase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3087] [UniProtKB: O43280]
ChEMBL	Inhibitory activity against trehalase from porcine kidney	B	4.4	pIC50	40000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5991-5995 [PMID:15546715]
Trehalase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3248] [UniProtKB: O70282]
ChEMBL	Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method	B	4.38	pIC50	42000	nM	IC50	J Med Chem (1995) 38: 2349-2356 [PMID:7608901]
ChEMBL	Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestine	B	4.38	pIC50	42000	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
ChEMBL	Inhibition of rat intestinal trehalase	B	4.38	pIC50	42000	nM	IC50	J Med Chem (2012) 55: 10347-10362 [PMID:23106358]
ChEMBL	Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidney	B	4.39	pIC50	41000	nM	IC50	J Med Chem (1994) 37: 3701-3706 [PMID:7966130]
Uncharacterized protein in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176863] [UniProtKB: I3LIR5]
ChEMBL	Inhibition of pig kidney trehalase assessed as p-nitrophenol release by spectrophotometrically	B	4.39	pIC50	41000	nM	IC50	J Nat Prod (2002) 65: 198-202 [PMID:11858756]
ChEMBL	Inhibition of porcine kidney trehalase	B	4.39	pIC50	41000	nM	IC50	J Med Chem (2012) 55: 10347-10362 [PMID:23106358]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]