nisoxetine [Ligand Id: 4637] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL295467 (COMPOUND 89218, LY-94939, Nisoxetine, NSC-283481) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | Binding affinity for dopamine transporter expressed in LCK PK1 cells | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2004) 47: 5258-5264 [PMID:15456270] |
| ChEMBL | In vitro competitive binding versus [N-methyl-3H]WIN-35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT) | B | 7.52 | pKi | 30 | nM | Ki | J Med Chem (2003) 46: 925-935 [PMID:12620070] |
| ChEMBL | Inhibition of dopamine uptake at human DAT expressed in HEK cells | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4495-4498 [PMID:18667309] |
| ChEMBL | Inhibition of dopamine uptake at human DAT in human HEK293 cells | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4224-4227 [PMID:18550369] |
| ChEMBL | Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay | B | 5.94 | pIC50 | 1150 | nM | IC50 | J Med Chem (2012) 55: 8188-8192 [PMID:22938049] |
| ChEMBL | Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | B | 5.94 | pIC50 | 1150 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340] |
| ChEMBL | Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 5.94 | pIC50 | 1150 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] | ||||||||
| ChEMBL | Binding affinity against dopamine transporter (DAT) by displacement of [3H]WIN-35428 in male wistar rats | B | 6.3 | pIC50 | >500 | nM | IC50 | J Med Chem (2003) 46: 5512-5532 [PMID:14640559] |
| NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
| ChEMBL | Inhibition of norepinephrine reuptake at NET | B | 8.22 | pKi | 6 | nM | Ki | Bioorg Med Chem (2009) 17: 7802-7815 [PMID:19836247] |
| GtoPdb | - | - | 8.4 | pKi | 3.98 | nM | Ki | |
| ChEMBL | Binding affinity for Norepinephrine transporter (NET) expressed in LCK PK1 cells | B | 8.8 | pKi | 1.6 | nM | Ki | J Med Chem (2004) 47: 5258-5264 [PMID:15456270] |
| ChEMBL | Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340] |
| ChEMBL | Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 7.7 | pIC50 | 20 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| ChEMBL | Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (2012) 55: 8188-8192 [PMID:22938049] |
| ChEMBL | Inhibition of norepinephrine uptake at human NET expressed in HEK cells | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4495-4498 [PMID:18667309] |
| ChEMBL | Inhibition of norepinephrine uptake at human NET in human HEK293 cells | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4224-4227 [PMID:18550369] |
| ChEMBL | Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation counting | B | 8.08 | pIC50 | 8.3 | nM | IC50 | Bioorg Med Chem (2011) 19: 663-676 [PMID:21093273] |
| ChEMBL | Inhibition of norepinephrine reuptake at NET expressed in MDCK cells | B | 8.1 | pIC50 | 7.94 | nM | IC50 | J Med Chem (2011) 54: 5283-5295 [PMID:21739935] |
| ChEMBL | Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation counting | B | 8.1 | pIC50 | 7.94 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1434-1437 [PMID:21310612] |
| ChEMBL | Inhibition of norepinephrine uptake at human NET expressed in MDCK cells | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4929-4931 [PMID:18771916] |
| ChEMBL | Inhibition of human NET expressed in COS7 cells assessed as inhibition of [3H]norepinephrine uptake | B | 8.99 | pEC50 | -8.99 | - | logEC50 | J Med Chem (2009) 52: 6991-7002 [PMID:19860431] |
| Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4] | ||||||||
| ChEMBL | Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar rats | B | 8 | pKi | 9.9 | nM | Ki | J Med Chem (2003) 46: 5512-5532 [PMID:14640559] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranes | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2003) 46: 5512-5532 [PMID:14640559] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranes | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2003) 46: 5512-5532 [PMID:14640559] |
| SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| ChEMBL | Binding affinity for serotonin transporter expressed in LCK PK1 cells | B | 6.69 | pKi | 203 | nM | Ki | J Med Chem (2004) 47: 5258-5264 [PMID:15456270] |
| ChEMBL | In vitro competitive binding versus [3H]-citalopram in murine kidney cells transfected with cDNA for human serotonin transporter (SERT) | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2003) 46: 925-935 [PMID:12620070] |
| ChEMBL | Inhibition of serotonin uptake at human SERT expressed in HEK cells | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4495-4498 [PMID:18667309] |
| ChEMBL | Inhibition of serotonin uptake at human SERT in human HEK293 cells | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4224-4227 [PMID:18550369] |
| ChEMBL | Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2012) 55: 8188-8192 [PMID:22938049] |
| ChEMBL | Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340] |
| ChEMBL | Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 6.15 | pIC50 | 700 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| ChEMBL | Inhibition of serotonin uptake at human SERT expressed in JAR cells | B | 6.56 | pIC50 | 277 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4929-4931 [PMID:18771916] |
| SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
| ChEMBL | Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometry | B | 6.56 | pKi | 277 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 58-61 [PMID:19038547] |
| ChEMBL | Binding affinity against serotonin transporter (SERT) by displacement of [3H]paroxetine in male wistar rats | B | 6.3 | pIC50 | >500 | nM | IC50 | J Med Chem (2003) 46: 5512-5532 [PMID:14640559] |
| Transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6184] [UniProtKB: Q63380] | ||||||||
| ChEMBL | Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometry | B | 8.22 | pKi | 6 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 58-61 [PMID:19038547] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
