[3H]nisoxetine [Ligand Id: 4636] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1628648 ([3H]-Nisoxetine)
  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Binding affinity to human NET S225H mutant expressed in african green monkey COS1 cells B 6.18 pKd 656 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
ChEMBL Binding affinity to human NET T381K mutant expressed in african green monkey COS1 cells B 6.19 pKd 650 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
ChEMBL Binding affinity to human NET F207T mutant expressed in african green monkey COS1 cells B 6.5 pKd 319 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
ChEMBL Binding affinity to human NET H296S mutant expressed in african green monkey COS1 cells B 6.59 pKd 257 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
ChEMBL Binding affinity to human NET D473A mutant expressed in african green monkey COS1 cells B 7.33 pKd 47 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
ChEMBL Binding affinity to human wild type NET expressed in african green monkey COS1 cells B 8.29 pKd 5.1 nM Kd J Biol Chem (2007) 282: 17837-17844 [PMID:17428804]
GtoPdb - - 8.4 pKd 4 nM Kd

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]