[3H]WIN35428 [Ligand Id: 4605] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1944829
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
GtoPdb - - 8 pKd 10 nM Kd Mol Pharmacol (1994) 45: 125-35 [PMID:8302271]
ChEMBL Displacement of [3H]WIN35428 from human cloned DAT receptor expressed in human HEK293 cells B 7.45 pKi 35.48 nM Ki Bioorg. Med. Chem. (2012) 20: 1388-1395 [PMID:22300887]
ChEMBL Displacement of [3H]WIN 35428 from human DAT transiently expressed in COS7 cells B 7.89 pKi 13 nM Ki J Med Chem (2020) 63: 2343-2357 [PMID:31661268]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]