[3H]WIN35428 [Ligand Id: 4605] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1944829
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
GtoPdb - - 8 pKd 10 nM Kd Mol Pharmacol (1994) 45: 125-35 [PMID:8302271]
ChEMBL Displacement of [3H]WIN35428 from human cloned DAT receptor expressed in human HEK293 cells B 7.45 pKi 35.48 nM Ki Bioorg Med Chem (2012) 20: 1388-1395 [PMID:22300887]
ChEMBL Displacement of [3H]WIN 35428 from human DAT transiently expressed in COS7 cells B 7.89 pKi 13 nM Ki J Med Chem (2020) 63: 2343-2357 [PMID:31661268]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]