ChEMBL ligand: CHEMBL6251
Amino acid transporter in Rat [ChEMBL: CHEMBL3562161] [UniProtKB: Q9Z1J7] There should be some charts here, you may need to enable JavaScript!
Alanine/serine/cysteine transporter 2 in Rat [GtoPdb: 874] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Amino acid transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3562161] [UniProtKB: Q9Z1J7]
ChEMBL	Inhibition of ASCT2-mediated glutamine transport in rat C6 cells using [3H]-glutamine after 15 mins by scintillation counting	B	4.15	pIC50	70200	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1044-1047 [PMID:26750251]
ChEMBL	Inhibition of ASCT2 mediated [3H]-L-serine uptake at high affinity component in rat hippocampal astrocytes after 5 mins by beta counting analysis	B	4.24	pIC50	57000	nM	IC50	US-8741955-B2. D-serine transporter inhibitors as pharmaceutical compositions for the treatment of central nervous system disorders (2014)
Alanine/serine/cysteine transporter 2 in Rat [GtoPdb: 874]
GtoPdb	-	-	4.26	pKi	55000	nM	Ki	Bioorg Med Chem (2005) 13: 1111-8 [PMID:15670919]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]