benzylcysteine [Ligand Id: 4501] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL63130 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Asc-type amino acid transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105976] [GtoPdb: 901] [UniProtKB: P63116] | ||||||||
| ChEMBL | Inhibition of asc-1 mediated [3H]-D-serine uptake in P2 fraction of rat forebrain synaptosomes after 4 mins by beta scintillation counting | B | 4.07 | pIC50 | 86000 | nM | IC50 | US-8741955-B2. D-serine transporter inhibitors as pharmaceutical compositions for the treatment of central nervous system disorders (2014) |
| kinesin-5/Kinesin-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4581] [GtoPdb: 2788] [UniProtKB: P52732] | ||||||||
| ChEMBL | Inhibition of Eg5 assessed as inhibition ATP hydrolysis by ATPase assay | F | 4.2 | pIC50 | >63000 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3921-3924 [PMID:17524640] |
| Alanine/serine/cysteine transporter 2 in Human [GtoPdb: 874] [UniProtKB: Q15758] | ||||||||
| GtoPdb | - | - | 3.11 | pKi | 780000 | nM | Ki | J Physiol (Lond.) (2004) 557: 747-59 [PMID:15107471] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
