salicylic acid [Ligand Id: 4306] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL424 (Salicylic acid, Freezone, Duofilm, Jadit, Salactol, Erytex, Pyralvex, FEMA NO. 3985, Keralyt, Salatac, Occlusal, 2-hydroxybenzoic acid, Compound v, Noxacorn, Salicylic acid rs, Dr. scholl's callus removers, Edinburgh, Phytocil, Phiso-clear, Metanium, Posalfilin, Acnisal, Verrugon, Gppe paint, Thwart, Toepedo, NSC-180, Lamivudine impurity, salicylic acid-, Cuplex verruca, Phytex, Wartex, Bazuka, Necol, Compound w, Lamivudine related compound salicylic acid, K-557) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
| ChEMBL | Inhibitory activity against binding of [125I]IMSB to amyloid beta in brain | B | 5.74 | pKi | >1800 | nM | Ki | J Med Chem (2001) 44: 2270-2275 [PMID:11428920] |
| carbonic anhydrase 1/Carbonic anhydrase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 5 | pKi | 9920 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 5 | pKi | 9900 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay | B | 5 | pKi | 9900 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662] |
| carbonic anhydrase 12/Carbonic anhydrase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay | B | 5.06 | pKi | 8800 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| carbonic anhydrase 13/Carbonic anhydrase 13 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay | B | 4.17 | pKi | 67000 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| carbonic anhydrase 14/Carbonic anhydrase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay | B | 4.3 | pKi | 49800 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay | B | 5.14 | pKi | 7200 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600] |
| carbonic anhydrase 2/Carbonic anhydrase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 5.15 | pKi | 7120 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 5.15 | pKi | 7100 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay | B | 5.15 | pKi | 7100 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662] |
| carbonic anhydrase 4/Carbonic anhydrase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay | B | 4.95 | pKi | 11100 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| Carbonic anhydrase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 6 by stopped-flow CO2 hydration assay | B | 4.92 | pKi | 11900 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| carbonic anhydrase 7/Carbonic anhydrase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay | B | 4.09 | pKi | 82100 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| carbonic anhydrase 9/Carbonic anhydrase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay | B | 4.1 | pKi | 78700 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| ChEMBL | Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay | B | 4.1 | pKi | 78700 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662] |
| high mobility group box 1/High mobility group protein B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2311236] [GtoPdb: 3279] [UniProtKB: P09429] | ||||||||
| ChEMBL | Binding affinity to recombinant HMGB1 box A (unknown origin) | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2018) 61: 5093-5107 [PMID:29268019] |
| ChEMBL | Binding affinity to recombinant HMGB1 box B (unknown origin) | B | 6 | pKd | 1000 | nM | Kd | J Med Chem (2018) 61: 5093-5107 [PMID:29268019] |
| Nicotinate phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6] | ||||||||
| ChEMBL | Inhibition of NAPRT (unknown origin) | B | 9.8 | pKi | 0.16 | nM | Ki | WO-2017162840-A1. Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization (2017) |
| COX-1 /Prostaglandin G/H synthase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibition of human COX1 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate incubated for 10 mins by ELISA | B | 4.4 | pIC50 | >40000 | nM | IC50 | Eur J Med Chem (2020) 193: 112217-112217 [PMID:32182488] |
| COX-2 /Prostaglandin G/H synthase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibition of human COX2 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate incubated for 10 mins by ELISA | B | 4.4 | pIC50 | >40000 | nM | IC50 | Eur J Med Chem (2020) 193: 112217-112217 [PMID:32182488] |
| OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1] | ||||||||
| ChEMBL | Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr | B | 4.36 | pKi | 44000 | nM | Ki | J Biol Chem (2007) 282: 23841-23853 [PMID:17553798] |
| ChEMBL | Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr | B | 4.36 | pKi | 43651.58 | nM | Ki | J Biol Chem (2007) 282: 23841-23853 [PMID:17553798] |
| Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713] | ||||||||
| ChEMBL | Inhibition of mushroom tyrosinase after 10 mins | B | 4 | pIC50 | 100000 | nM | IC50 | J Med Chem (2011) 54: 591-602 [PMID:21189019] |
| ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3] | ||||||||
| GtoPdb | - | - | 3.6 | pIC50 | 260000 | nM | IC50 | J Neurosci (2001) 21: 8026-33 [PMID:11588175] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
