RO3 [Ligand Id: 4298] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL494772
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
P2X3/P2X2/P2X2/P2X3 heterotrimeric receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3831281] [GtoPdb: 480, 479] [UniProtKB: P56373, Q9UBL9]
ChEMBL Antagonist activity at human recombinant P2X2/3 receptor expressed in human 1321N1 cells by FLIPR assay F 5.7 pIC50 1995.26 nM IC50 Bioorg Med Chem Lett (2009) 19: 1628-1631 [PMID:19231180]
GtoPdb - - 7.5 pIC50 ~31 nM IC50 Br J Pharmacol (2006) 147 Suppl 2: S132-43 [PMID:16465177]
P2X3 in Human [GtoPdb: 480] [UniProtKB: P56373]
GtoPdb - - 7.5 pIC50 ~31 nM IC50 Br J Pharmacol (2006) 147 Suppl 2: S132-43 [PMID:16465177]
P2X3/P2X purinoceptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654]
ChEMBL Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assay F 6.9 pIC50 125.89 nM IC50 Bioorg Med Chem Lett (2009) 19: 1628-1631 [PMID:19231180]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]