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ChEMBL ligand: CHEMBL494772 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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P2X3/P2X2/P2X2/P2X3 heterotrimeric receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3831281] [GtoPdb: 480, 479] [UniProtKB: P56373, Q9UBL9] | ||||||||
ChEMBL | Antagonist activity at human recombinant P2X2/3 receptor expressed in human 1321N1 cells by FLIPR assay | F | 5.7 | pIC50 | 1995.26 | nM | IC50 | Bioorg. Med. Chem. Lett. (2009) 19: 1628-1631 [PMID:19231180] |
GtoPdb | - | - | 7.5 | pIC50 | ~31 | nM | IC50 | Br J Pharmacol (2006) 147 Suppl 2: S132-43 [PMID:16465177] |
P2X3 in Human [GtoPdb: 480] [UniProtKB: P56373] | ||||||||
GtoPdb | - | - | 7.5 | pIC50 | ~31 | nM | IC50 | Br J Pharmacol (2006) 147 Suppl 2: S132-43 [PMID:16465177] |
P2X3/P2X purinoceptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654] | ||||||||
ChEMBL | Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assay | F | 6.9 | pIC50 | 125.89 | nM | IC50 | Bioorg. Med. Chem. Lett. (2009) 19: 1628-1631 [PMID:19231180] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]