RO3 [Ligand Id: 4298] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL494772
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
P2X3/P2X2/P2X2/P2X3 heterotrimeric receptor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3831281] [GtoPdb: 480, 479] [UniProtKB: P56373, Q9UBL9]
ChEMBL Antagonist activity at human recombinant P2X2/3 receptor expressed in human 1321N1 cells by FLIPR assay F 5.7 pIC50 1995.26 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 1628-1631 [PMID:19231180]
GtoPdb - - 7.5 pIC50 ~31 nM IC50 Br J Pharmacol (2006) 147 Suppl 2: S132-43 [PMID:16465177]
P2X3 in Human [GtoPdb: 480] [UniProtKB: P56373]
GtoPdb - - 7.5 pIC50 ~31 nM IC50 Br J Pharmacol (2006) 147 Suppl 2: S132-43 [PMID:16465177]
P2X3/P2X purinoceptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4824] [GtoPdb: 480] [UniProtKB: P49654]
ChEMBL Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assay F 6.9 pIC50 125.89 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 1628-1631 [PMID:19231180]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]