ChEMBL ligand: CHEMBL1503 (Antra, H 168/68, H-168/68, Losec, Losec mups, Mezzopram, Mopral, NSC-751450, NSC-759192, Omeprazole, Omeran, Prilosec, Zanprol)
BB3 receptor/Bombesin receptor subtype-3 in Human [ChEMBL: CHEMBL4080] [GtoPdb: 40] [UniProtKB: P32247] There should be some charts here, you may need to enable JavaScript!
Endo-beta-N-acetylglucosaminidase in Human [ChEMBL: CHEMBL5172] [UniProtKB: Q8NFI3] There should be some charts here, you may need to enable JavaScript!
fatty acid synthase/Fatty acid synthase in Human [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327] There should be some charts here, you may need to enable JavaScript!
glutathione S-transferase omega 1/Glutathione transferase omega 1 in Human [ChEMBL: CHEMBL3174] [GtoPdb: 3110] [UniProtKB: P78417] There should be some charts here, you may need to enable JavaScript!
NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
ATP4A/ATP4B/Potassium-transporting ATPase in Human [ChEMBL: CHEMBL2095173] [GtoPdb: 849, 851] [UniProtKB: P20648, P51164] Potassium-transporting ATPase in Pig [ChEMBL: CHEMBL2095228] [UniProtKB: P18434, P19156] There should be some charts here, you may need to enable JavaScript!
sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4/Sodium/potassium-transporting ATPase in Human [ChEMBL: CHEMBL2095186] [GtoPdb: 833, 837, 835, 838, 834, 839, 2610, 836] [UniProtKB: P05023, P05026, P13637, P14415, P50993, P54709, P54710, Q13733] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
BB3 receptor/Bombesin receptor subtype-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4080] [GtoPdb: 40] [UniProtKB: P32247]
ChEMBL	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	F	4.85	pEC50	14000	nM	EC50	Bioorg. Med. Chem. Lett. (2008) 18: 5451-5455 [PMID:18818070]
Endo-beta-N-acetylglucosaminidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5172] [UniProtKB: Q8NFI3]
ChEMBL	Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreated for 15 mins followed by substrate addition after 90 mins by SDS-PAGE analysis	B	4.6	pIC50	25000	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2962-2966 [PMID:28512024]
fatty acid synthase/Fatty acid synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327]
ChEMBL	Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition measured after 1 hr by fluorescence assay	B	5.47	pKi	3400	nM	Ki	J. Med. Chem. (2015) 58: 778-784 [PMID:25513712]
ChEMBL	Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition measured after 1 hr by fluorescence assay	B	4.53	pIC50	29600	nM	IC50	J. Med. Chem. (2015) 58: 778-784 [PMID:25513712]
glutathione S-transferase omega 1/Glutathione transferase omega 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3174] [GtoPdb: 3110] [UniProtKB: P78417]
ChEMBL	Inhibition of GSTO1-1 (unknown origin) by enzymatic assay	B	5.34	pIC50	4600	nM	IC50	J Med Chem (2018) 61: 7448-7470 [PMID:29652143]
NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760]
ChEMBL	Inhibition of recombinant human DDAH1 expressed in Escherichia coli BL21 Star (DE3) using ADMA as substrate assessed as decrease in citrulline production after 4 hrs by colorimetric method	B	4.7	pIC50	20000	nM	IC50	WO-2014160947-A1. Dimethylarginine Dimethylaminohydrolase inhibitors and methods of use thereof (2014)
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity model	B	4.01	pIC50	97200	nM	IC50	J. Med. Chem. (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL	Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity model	B	4.04	pIC50	91200	nM	IC50	J. Med. Chem. (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL	Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity model	B	4.05	pIC50	89000	nM	IC50	J. Med. Chem. (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL	TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells	F	4.75	pIC50	17700	nM	IC50	Naunyn Schmiedebergs Arch. Pharmacol. (2001) 364: 551-557 [PMID:11770010]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells	F	6.17	pIC50	680	nM	IC50	Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	4.12	pIC50	76000	nM	IC50	Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	HARVARD: Inhibition of blood stage Plasmodium falciparum 3D7 infection	F	4.3	pIC50	>50000	nM	IC50	Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
ChEMBL	HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection	F	4.3	pIC50	>50000	nM	IC50	Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	4.88	pIC50	13230	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ATP4A/ATP4B/Potassium-transporting ATPase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095173] [GtoPdb: 849, 851] [UniProtKB: P20648, P51164]
ChEMBL	Compound was tested in vitro for H+/K+ ATPase activity in rabbit stomach preparations	B	4.65	pIC50	22400	nM	IC50	Bioorg. Med. Chem. Lett. (1999) 9: 2819-2822 [PMID:10522698]
ChEMBL	Inhibition of H+/K+ ATPase activity in buffered solution (pH 7.4)	B	5.42	pIC50	3800	nM	IC50	Bioorg. Med. Chem. Lett. (1998) 8: 1909-1912 [PMID:9873457]
ChEMBL	In vitro inhibitory activity against H+/K+ ATPase prepared from canine fundic mucosa	B	5.7	pIC50	2000	nM	IC50	J. Med. Chem. (1988) 31: 1215-1220 [PMID:2836591]
ChEMBL	In vitro evaluation for the inhibition of H+/K+ ATPase at pH < 3 in the gastric glands of isolated rabbit stomach.	B	6.3	pIC50	501.19	nM	IC50	J. Med. Chem. (1992) 35: 1049-1057 [PMID:1313110]
ChEMBL	Inhibition of [14C]aminopyrine (AP) accumulation stimulated by dibutyryl cyclic AMP in isolated rabbit parietal cells	F	6.43	pIC50	370	nM	IC50	J. Med. Chem. (1997) 40: 313-321 [PMID:9022797]
ChEMBL	Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5' -monophosphate (dcAMP)	F	6.55	pIC50	280	nM	IC50	J. Med. Chem. (1988) 31: 1778-1785 [PMID:2842503]
ChEMBL	Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine	F	6.6	pIC50	250	nM	IC50	J. Med. Chem. (1988) 31: 1778-1785 [PMID:2842503]
Potassium-transporting ATPase in Pig (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095228] [UniProtKB: P18434, P19156]
ChEMBL	Activity was evaluated by measuring the inhibition of isolated hog H+/K+ ATPase	B	4.3	pIC50	50000	nM	IC50	J. Med. Chem. (1991) 34: 1049-1062 [PMID:1848293]
ChEMBL	In vitro inhibition against H+/K+ ATPase from porcine gastric mucosal membrane vesicles	B	5.42	pIC50	3800	nM	IC50	J. Med. Chem. (1996) 39: 596-604 [PMID:8558532]
sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4/Sodium/potassium-transporting ATPase in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095186] [GtoPdb: 833, 837, 835, 838, 834, 839, 2610, 836] [UniProtKB: P05023, P05026, P13637, P14415, P50993, P54709, P54710, Q13733]
ChEMBL	In vitro evaluation for its ability to inhibit the Na+/K+ ATPase at pH 7.4.	B	4.5	pIC50	31622.78	nM	IC50	J. Med. Chem. (1992) 35: 1049-1057 [PMID:1313110]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]