NPPB [Ligand Id: 4270] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1256759 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Px1/Pannexin-1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879520] [GtoPdb: 735] [UniProtKB: Q9JIP4] | ||||||||
| ChEMBL | Inhibition of mouse Panx-1 expressed in Xenopus laevis oocytes assessed as inhibition of membrane current cells held at -60 mV and voltage steps to +60 mV in presence of CBX measured by Whole cell voltage clamp assay relative to control | B | 4.3 | pIC50 | 50000 | nM | IC50 | Eur J Med Chem (2021) 223: 113650-113650 [PMID:34174741] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 6.22 | pEC50 | 602.56 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 6.22 | pEC50 | 600 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| GtoPdb | FLIPR calcium influx assay | - | 6.49 | pEC50 | - | - | - | Biochem Pharmacol (2010) 80: 113-21 [PMID:20226176] |
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by FLIPR analysis | B | 6.49 | pEC50 | 320 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| ClC-7 in Human [GtoPdb: 706] [UniProtKB: P51798] | ||||||||
| GtoPdb | - | - | 3.8 | pIC50 | 156000 | nM | IC50 | PLoS ONE (2010) 5: e12585 [PMID:20830208] |
| Maxi Cl- in Human [GtoPdb: 709] | ||||||||
| GtoPdb | - | - | 3.8 | pIC50 | 156000 | nM | IC50 | PLoS ONE (2010) 5: e12585 [PMID:20830208] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
