ChEMBL ligand: CHEMBL1551597
Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975] There should be some charts here, you may need to enable JavaScript!
Cav3.2/Voltage-gated T-type calcium channel alpha-1H subunit in Human [ChEMBL: CHEMBL1859] [GtoPdb: 536] [UniProtKB: O95180] There should be some charts here, you may need to enable JavaScript!
CatSper1 in Human [GtoPdb: 388] [UniProtKB: Q8NEC5] CatSper1 in Mouse [GtoPdb: 388] [UniProtKB: Q91ZR5] There should be some charts here, you may need to enable JavaScript!
CatSper2 in Human [GtoPdb: 389] [UniProtKB: Q96P56] CatSper2 in Mouse [GtoPdb: 389] [UniProtKB: A2ARP9] There should be some charts here, you may need to enable JavaScript!
CatSper3 in Human [GtoPdb: 390] [UniProtKB: Q86XQ3] CatSper3 in Mouse [GtoPdb: 390] [UniProtKB: Q80W99] There should be some charts here, you may need to enable JavaScript!
CatSper4 in Human [GtoPdb: 391] [UniProtKB: Q7RTX7] CatSper4 in Mouse [GtoPdb: 391] [UniProtKB: Q8BVN3] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975]
ChEMBL	Inhibition of Cav2.2 in human SH-SY5Y cells assessed as inhibition of calcium influx measured for 300 secs in presence of Cav1 blocker, nifedipine by FLIPR assay	B	4.61	pIC50	24300	nM	IC50	RSC Med Chem (2024) 15: 916-936 [PMID:38516585]
Cav3.2/Voltage-gated T-type calcium channel alpha-1H subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1859] [GtoPdb: 536] [UniProtKB: O95180]
ChEMBL	Inhibition of human recombinant Cav3.2 alpha1 subunit expressed in HEK293T cells assessed as inhibition of calcium influx measured for 300 secs by FLIPR assay	B	4.51	pIC50	30900	nM	IC50	RSC Med Chem (2024) 15: 916-936 [PMID:38516585]
CatSper1 in Human [GtoPdb: 388] [UniProtKB: Q8NEC5]
GtoPdb	Patch clamp electrophysiology, kinetic rapid mixing fluometry	-	5.7	pIC50	2000	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]; Nature (2011) 471: 382-6 [PMID:21412338]
CatSper1 in Mouse [GtoPdb: 388] [UniProtKB: Q91ZR5]
GtoPdb	Patch clamp electrophysiology	-	5.6	pIC50	>2500	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]
CatSper2 in Human [GtoPdb: 389] [UniProtKB: Q96P56]
GtoPdb	Patch clamp electrophysiology and kinetic rapid mixing fluometry.	-	5.7	pIC50	2000	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]; Nature (2011) 471: 382-6 [PMID:21412338]
CatSper2 in Mouse [GtoPdb: 389] [UniProtKB: A2ARP9]
GtoPdb	Patch clamp electrophysiology.	-	4.6	pIC50	>25000	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]
CatSper3 in Human [GtoPdb: 390] [UniProtKB: Q86XQ3]
GtoPdb	Patch clamp electrophysiology, kinetic rapid mixing fluometry.	-	5.7	pIC50	2000	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]; Nature (2011) 471: 382-6 [PMID:21412338]
CatSper3 in Mouse [GtoPdb: 390] [UniProtKB: Q80W99]
GtoPdb	Patch clamp electrophysiology.	-	5.6	pIC50	>2500	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]
CatSper4 in Human [GtoPdb: 391] [UniProtKB: Q7RTX7]
GtoPdb	Patch clamp electrophysiology, kinetic rapid mixing fluometry.	-	5.7	pIC50	2000	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]; Nature (2011) 471: 382-6 [PMID:21412338]
CatSper4 in Mouse [GtoPdb: 391] [UniProtKB: Q8BVN3]
GtoPdb	Patch clamp electrophysiology.	-	5.6	pIC50	>2500	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]