clomiphene [Ligand Id: 4159] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2355051 (Clomifene, Clomifeno, Clomiphene)
  • Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
Created with Highcharts 10.3.3ValuesChart context menuAndrogen ReceptorpKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuPlasmodium bergheipKd Plasmodium bergheipKi Plasmodium bergheipIC50 Plasmodium bergheipEC50 Plasmodium berghei02468Highcharts.com
  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 6 (5-HT6) receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Estrogen receptor-α in Human [GtoPdb: 620] [UniProtKB: P03372]
Created with Highcharts 10.3.3ValuesChart context menuEstrogen receptor-αpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) B 4.87 pIC50 13489.63 nM IC50 J Med Chem (2005) 48: 5666-5674 [PMID:16134935]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells F 6.66 pIC50 219 nM IC50 Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting B 5.71 pKi 1956 nM Ki J Med Chem (2012) 55: 5704-5719 [PMID:22537153]
Estrogen receptor-α in Human [GtoPdb: 620] [UniProtKB: P03372]
GtoPdb - - 8.89 pKi 1.3 nM Ki National Toxicology Program: Dept of Health and Human Services.. DrugMatrix

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]